IRCT2015070220178N5 IRCT 2015-08-12 Iran University of Medical Sciences,Rasoul Akram Hospital,Colorectal Research Center Efficacy of pantoprazole suspension for prevention of peptic ulcer. A comparison of nasogastric pantoprazole suspension and intravenouse pantoprazole in prevention of peptic ulcer for critically ill patients with mechanical ventilation support: effects on 24-h intragastric pH. 2015-07-23 anticipated 66 Complete https://irct.ir/trial/17894 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 3 peptic ulcer prevention. Intervention 1: group A:pantoprazole, 40 mg intravenous once daily.The IV solution will be prepared by injecting 10 ml of 0.9% sodium chloride injection into the vial containing the lyophilized powder.This solution will be then further dilluted with 90 ml of sodium chloride injection,The reconstituted solution will be infused over a period of 15 minutes. Intervention 2: group B: 25 cc of 2mg/ml simplified formulated pantoprazole suspension ( 50 mg pantoprazole) once daily nasogastrically and according to 75% bioavailability for suspension at last this dose equal to pantoprazole tablet 40mg.The pantoprazole suspension is prepared four hours before administration. Two 40-mg pantoprazole tablet is ground into a fine powder . The powder is transferred to a glass container, and rinsed twice with 10 mL of 4.2% (0.5 M) sodium bicarbonate solution. The container is closed and shaked for 10 minutes until a uniform suspension formed. The suspension is transferred to a 40-mL polypropylene syringe. The glass container is rinsed twice with 10 mL of 4.2% sodium bicarbonate solution again, and the suspension is added to the syringe. The total volume of the suspension is 40 mL, and the pantoprazole concentration is 2 mg/mL. The suspension is protected from light.