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IRCT2014121020272N1 IRCT 2015-08-24 Deputy for research Zahedan University of Medical Sciences Effect of pregabalin on hemodynamic on pain Effect of a single dose of Pregabalin on intraoperative hemodynamic changes and duration of analgesia in spinal anesthesia for tibial bone fracture orthopedic surgery 2014-03-20 anticipated 120 Complete https://irct.ir/trial/18012 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive. 4 Spinal anesthesia. Intervention 1: pregabalin group (150 mg capsule): because of 150 mg capsules it's not available on the market of Iran that is given two 75 mg capsules instead. A hour before spinal anesthesia is used by nurses in the orthopedic unite, who was not aware of drugs the patient is given effect by comparison with the placebo group on the dependent variables arterial medium voltage, pulse duration of analgesia after spinal anesthesia are considered. Intervention 2: placebo group (Appearance, but no active ingredient drug capsules ). A hour before spinal anesthesia is used by nurses in the orthopedic unite, who was not aware of drugs the patient is given effect by comparison with the placebo group on the dependent variables arterial medium voltage, pulse duration of analgesia after spinal anesthesia are considered.
public Amir Moosavi
Khatam Hospital, Jame Jam Boulevard
Zahedan Iran (Islamic Republic of) 9815733169 +98 54 3322 0501 amir.moosavi@zaums.ac.ir Zahedan University of Medical Sciences scientific Alireza Rahat Dahmardeh
Khatam Hospital, Jame Jam Boulevard
Zahedan Iran (Islamic Republic of) 9815733169 +98 915 542 0911 Dr.dahmardeh@gmail.com Zahedan Medical Science Univesity Iran (Islamic Republic of) Inclusion criteria: The non-emergency patients ASA class 1; Age 20 to 70 years; candidates for orthopedic surgery tibia fracture; the prior written consent from patient; social class and level of consciousness that patient is able to cooperate ;    Exclusion criteria were the beginning of the study: hemodynamic status is affected with diseases or conditions such as heart disease, diabetes, renal ;The history of allergy to gabapentin or Pregabalin, drug use, regular use of alcohol or smoking more than 5 years, the diseases of the brain and nerves ; spinal anesthesia during surgery after more than ninety minutes ; patients who require drugs that affect hemodynamic ; pregnancy ; refusal of doing research and refusal of spinal anesthesia patients ; patients with coagulopathy ; infection in site of the spinal anesthesia ; any interference with the absorption of oral drugs that can cause digestive disorders ; The disease affects the feeling of pain, such as diabetes, drug addiction ; Monitor the patient is indicative of Abnormal pulse , mean arteria presure ; The need for analgesics for pain relief      Exclusion criteria during the study: Abnormal bleeding during surgery ; Intraoperative cardiovascular and brain complications ; Monitor the patient is indicative of abnormal pulse, mean arterial pressure. 20 years 70 years Both T88.7 Unspecified adverse effect of drug or medicament Other Treatment - Drugs pregabalin group (150 mg capsule): because of 150 mg capsules it's not available on the market of Iran that is given two 75 mg capsules instead. A hour before spinal anesthesia is used by nurses in the orthopedic unite, who was not aware of drugs the patient is given effect by comparison with the placebo group on the dependent variables arterial medium voltage, pulse duration of analgesia after spinal anesthesia are considered. placebo group (Appearance, but no active ingredient drug capsules ). A hour before spinal anesthesia is used by nurses in the orthopedic unite, who was not aware of drugs the patient is given effect by comparison with the placebo group on the dependent variables arterial medium voltage, pulse duration of analgesia after spinal anesthesia are considered. Mean arterial pressure؛ pulse. Timepoint: Thirty minutes before feeding capsules every ten minutes. Every ten minutes after spinal anesthesia to complete the surgery. Method of measurement: Monitoring of vital signs. Duration of analgesia in spinal anesthesia. Timepoint: After the onset of anelgesia by spinal anesthesia Until the onset of pain. Method of measurement: Timer(minute). No exist. Timepoint: No exist. Method of measurement: No exist. Deputy for research Zahedan University of Medical Sciences Approved 2014-09-28 Zahedan University of Medical Sciences Doctor Hesab square Zahedan Iran (Islamic Republic of)