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IRCT138804302210N1 IRCT 2010-06-06 Sabzevar university of medical science Effect of Glucose-Insulin-Potassium on patients with Acute ST-Segment-Elevation Myocardial Infarction GIK Effect of Glucose-Insulin-Potassium on patients with Acute ST-Segment-Elevation Myocardial Infarction 2008-09-22 anticipated 70 Complete https://irct.ir/trial/1836 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Patients with ST elevation myocardial infarction. Intervention 1: Insulin Potassium Glucose ( 25% glucose, 50 IU of soluble insulin per liter, and 80 mmol of potassium chloride per liter) infused at 1.5 ml/kg/hour to GIK group in addition to 1.5 MU of streptokinase in 30 to 60 minutes. Intervention 2: 1 L normal saline at 60 mL/h in addition to streptokinase(1.5 MU in 30-60 minuts) infused to control group.
public Maryam Hashemian
Medical school-Tehran road
Sabzevar Iran (Islamic Republic of) 9613873136 +98 57 1444 6070 medical-school@medsab.ac.ir Sabzevar university of medical science scientific Maryam Hashemian
Medical school-Tehran road
Sabzevar Iran (Islamic Republic of) 9613873136 +98 57 1444 6070 hashemian3@yahoo.com Sabzevar university of medical science Iran (Islamic Republic of) Inclusion:All consecutive patients who had 20 minutes chest pain or its equivalent, time from symptom onset <12 hours, and had ST elevation ≥1 mm in ≥2 contiguous electrocardiographic leads when admitted to the Coronary Care Unit of the vaseie general hospital (Sabzevar ,Iran) were recruited. Exclusion: Patient with systemic infection, glucocorticoid therapy, hypo tension, congestive heart failure, creatinine >2.0 mg/dL and anemia (hemoglobin <11 g/dL), were excluded. Further exclusion criteria were unwillingness to participate. no limit no limit Both I21 Acute myocardial infarction Treatment - Drugs Placebo Insulin Potassium Glucose ( 25% glucose, 50 IU of soluble insulin per liter, and 80 mmol of potassium chloride per liter) infused at 1.5 ml/kg/hour to GIK group in addition to 1.5 MU of streptokinase in 30 to 60 minutes 1 L normal saline at 60 mL/h in addition to streptokinase(1.5 MU in 30-60 minuts) infused to control group Plasma CRP level in the control and GIK groups. Timepoint: 0, 6, 24 and 48 hours after admission. Method of measurement: ELIZA kit. Plasma CK and CK-MB and cardiac troponin I concentrations. Timepoint: 0, 16 and 24 hours after admission. Method of measurement: ELIZA kit. ST-segment resolution. Timepoint: 60 minutes after thrombolytic therapy. Method of measurement: ECG. Pain. Timepoint: 0,1 and 2 hours after thrombolytic therapy. Method of measurement: Interview. Arrythmia. Timepoint: 7 days after admission. Method of measurement: Cardiac monitoring by a physician. Re infarction. Timepoint: 7 days after admission. Method of measurement: Recurrent ST elevation of 0.1 mv or recurrent increase in creatinin kinase MB. Mortality. Timepoint: 7 days after admission. Method of measurement: Any death when cardiac death could not be excluded. Ejection fraction. Timepoint: 72 hours after admission. Method of measurement: Echocardiography. Sabzevar university of medical science Approved 2008-03-11 Sabzevar university of medical science Sabzevar university of medical science-Tehran road Sabzevar Iran (Islamic Republic of)