IRCT138805012220N1 IRCT 2009-11-01 Vice-Chancellor for Research,Shahid Beheshti University of Medical Science Infection rate after cholecystectomy IRAC Infections after laparoscopic and open cholecystectomy; Ceftriaxone versus placebo; a randomized clinical trial 2006-08-11 anticipated 130 Complete https://irct.ir/trial/1841 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Other design features: After explanation of surgical methods and study protocol we divided the patients into two groups by a table of random numbers. Group A undergone open cholecystectomy (OC) and group B undergone Laparoscopic Cholecystectomy (LC). Lab tests (CBC/diff, AST, ALT, serum billirubin, ALK-Ph) were checked for all patients before surgery. All surgeries were performed with the same surgery team who were expert in both methods. In each group patients randomly divided into two subgroups: first group received 1 gram Ceftriaxone during induction of anesthesia and the second group received 10 ml of isotonic sodium chlorides solution as placebo.drugs are injected by Anesthesiologist and neither the surgery team,who follow the patients,nor the patient know about the type of drug recieved . None of the patients received extra dosage of antibiotics (AB) during/after surgery. We compare patients according to demographic features, body weight ASA score, frequency of empyema, hydrops of gall bladder, cholecystitis, gall stones /polyps at time of admission, mean time of surgery and hospital stay, complications of surgery and infection rate, in each surgery method and compare the role of prophylactic antibiotic in reducing infection rate. 3 Condition 1: symptomatic gallstones. Condition 2: polyps of gallbladder. Intervention 1: single dose of ceftriaxone, 1 gr. during induction of anesthesia. Intervention 2: single dose of normal saline ,10 cc during induction of anesthesia. Intervention 3: laparoscopic cholecystectomy. Intervention 4: open cholecystectomy.