]>
IRCT2015021221014N2 IRCT 2015-12-29 Bandare-abbas University of Medical Sciences The study of Date Palm Pollen effect on sperm parameters in infertile men Evaluation of Date Palm Pollen on the expression of PRDX1 and PRDX6 antioxidant genes in infertile men 2016-03-27 anticipated 60 Complete https://irct.ir/trial/18526 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Participants entered the study after signing a personal and written consent form based on inclusion criteria.Their cement sample was measured before and after treatment with Date Palm Pollen capsule for 74 days in the case group and also the sample of the control group was measured according to the WHO 2010 analysis analysis guidelines. Also, the concentration of 8-Isoprostane,antioxidant genes was examined, Randomization description: Simple randomization with sealed envelope, Blinding description: .The patien Have been received medicine in sealed encoded envelopes. The coding is done by one of the project partners and they are blind evaluators. 2 Male infertility. Intervention 1: In addition to standard treatment by a urologist, the case group received 400 mg / kg of Date palm pollen powder in gelatin capsules for 74 days. Intervention 2: Intervention Control: Vitamin E 400 unit per day; L-Carnitine daily. Yes - There is a plan to make this available What will be shared: The study results will be published as an article. The study protocol and statistical analysis used in the article will be considered. When: It will be published a year after the study is completed and will be available in the sources. To whom: Information will be made available after permission of the sponsor for academic researchers, physicians and academic institutions. Conditions: Other researchers can use the results of the study in their review and meta-analysis. Where to obtain: Dr Soghra fallahi, PhD by research, Hormozgan university of medical science How to obtain: upon request, the corresponding author will respond after consulting with the sponsor of the study Comments:
public Kianoosh malekzadeh
fertility and infertility Research Center of Shahid Mohammadi Hospital, Bandar Abbas, Iran
Bandar abbas Iran (Islamic Republic of) 7919915519 +98 76 3333 7192 Keyanoosh@gmail.com Bandare-abbas University of Medical Sciences scientific Kianoosh malekzadeh
Kamarbandi St., Islamic Republic Boulevard, Shahid Mohammadi Hospital, fertility and Infertility Research Center, Bandar Abbas, Iran
Bandar abbas Iran (Islamic Republic of) 7915915517 +98 76 3333 7192 Keyanoosh@gmail.com Molecular Medicine Research Center Iran (Islamic Republic of) Normal anatomy of the genital area Infertility due to oligo asthenospermia 20 years 45 years Male The case with the following criteria were excluded from the study: history of genetic and systemic disorders. reproductive tract abnormality testicular trauma alcohol and substance abuse and fertility medications at least for six months before participation N46 Azoospermia NOS Oligospermia NOS Treatment - Drugs Treatment - Drugs In addition to standard treatment by a urologist, the case group received 400 mg / kg of Date palm pollen powder in gelatin capsules for 74 days. Intervention Control: Vitamin E 400 unit per day; L-Carnitine daily Change in count, Motility and morphology of sperm. Timepoint: 74 days after intervention. Method of measurement: Semen analysis. Change in PRDX1,PRDX6 antioxidant gene expression. Timepoint: 74 days after intervention. Method of measurement: evaluation of gene expression using Real time PCR Method. Semen samples were obtained twice from the case group, before and after treatment, and once from the control group through masturbation, masturbation and abstinence for three to five days. We then collected fresh semen samples in sterile plastic containers. Timepoint: 74 days after consumption of Date Palm Pollen. Method of measurement: The samples were exposed to 37 ° C for 30 minutes for liquefaction and semen analysis (fluid volume, pH,viscosity, sperm morphology, concentration and motility) was performed immediately according to the WHO guideline. Sex hormones were also examined using ELISA. In addition, in this clinical trial, a blind and comparative semen analysis was performed by a technician blindly. Bandare-abbas University of Medical Sciences Approved 2015-03-16 Ethics Committee of Molecular Medical Research Center of Bandar Abbas University of Medical Sciences Kamarbandi St., Jomhuri Eslami Boulevard,Shahid Mohammadi Hospital,Molecular Medicine Laboratory, Bandar Abbas, Iran Bandar abbas Hormozgan Iran (Islamic Republic of)