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IRCT2016011621087N1 IRCT 2016-01-16 Pooyesh Darou company and Shahid Beheshti University of Medical Sciences Erythropoietin effect on ischemic_reperfusion injury Erythropoietin effect on ischemic_reperfusion injury in cronary artery bypass graft surgery 2016-01-21 anticipated 90 Complete https://irct.ir/trial/18564 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Ischemic reperfusion injury in chronic artery bypass graft surgery. Intervention 1: Infusion of 50cc normal saline as placebo in control group, during aortic clamping(45-60 minutes). Intervention 2: Infusion of 60000 IU erythropoietin in intervention group,during aortic clamping (45-60 minutes).
public dr foroughi
Shahid Modarres hospital
tehran Iran (Islamic Republic of) +98 917 161 3954 mahnoosh.foroughi@gmail.com heart surgery department ofShahid Modarres hospital scientific dr foroughi
Shahid Modarres hospital
tehran Iran (Islamic Republic of) +98 917 161 3954 mahnoosh.foroughi@gmail.com heart surgery department of Shahid Modarres hospital Iran (Islamic Republic of) The inclusion criterion are revascularization requirement according to angiographic evidence,cronary artery bypass graft (CABG) surgery in elective situation, for the first time and with cardiopulmonary bypass(CPB). The exclusion criteria are comprised of history of myocardial infarction in the past 3 months, previous myocardial trauma or major surgery in the past 3 months, Cr>2, receiving streptokinase or previous reperfusion treatments, EPO intake in the recent 6 months, known thrombo-embolic disorder, malignant disease,uncontrolled hypertension and polycythemia 18 years 80 years Both I25.1,I25. Chronic ischaemic heart disease Treatment - Drugs Treatment - Drugs Infusion of 50cc normal saline as placebo in control group, during aortic clamping(45-60 minutes) Infusion of 60000 IU erythropoietin in intervention group,during aortic clamping (45-60 minutes) Interleukin 6. Timepoint: before operation (base),just after operation,24 hours after operation,48 hours after operation. Method of measurement: elisa. YKL-40. Timepoint: before operation (base),just after operation,24 hours after operation,48 hours after operation. Method of measurement: elisa. TNF-a. Timepoint: before operation (base),just after operation,24 hours after operation,48 hours after operation. Method of measurement: elisa. Added at 2016-09-22: B type natriuretic peptide(BNP. Timepoint: before operation (base),just after operation,24 hours after operation,48 hours after operation. Method of measurement: Added at 2016-09-22: ELISA. CPK-MB. Timepoint: befor operation(base),6 hour after operation,12 hour after operation. Method of measurement: elisa. Bleeding. Timepoint: during operation,6 hour after operation,12 hour after operation,24 hour after operation. Method of measurement: volume of bleeeding. Troponin. Timepoint: befor operation(base),6 hour after operation,12 hour after operation. Method of measurement: elisa. Pooyesh Darou company and Shahid Beheshti University of Medical Sciences Approved 2015-10-18 ethics committee of Shahid Beheshti university of medical science Shahid Beheshti university of medical science tehran Iran (Islamic Republic of)