IRCT2015030421327N1 IRCT 2015-04-25 Isfahan University of Medical Sciences Comparison of the induction of anesthesia by Propofol or Thiopental sodium or Etomidate during microlaryngeal surgery Comparison of the effect of induction of anesthesia by Propofol or Thiopental sodium or Etomidate on hemodynamic changes during microlaryngeal surgery 2013-01-20 anticipated 75 Complete https://irct.ir/trial/18721 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A General anesthasia. Intervention 1: Propofol, 2.2 mg/kg within 30 seconds; IV. Intervention 2: Thiopental sodium, 5 mg/kg within 30 seconds; IV. Intervention 3: Etomidate, 0.3 mg/kg within 30 seconds; IV.

public Dr Mehrdad Masoudifar

Alzahra medical center, Soffeh Blv.

Isfahan Iran (Islamic Republic of) +98 31 3625 5555 masoudifar@med.mui.ac.ir Isfahan University of Medical Scineces scientific Dr Mehrdad Masoudifar

Alzahra medical center, Soffeh Blv.

Isfahan Iran (Islamic Republic of) +98 31 3625 5555 masoudifar@med.mui.ac.ir Isfahan University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: age of 17-80; American Society of Anesthesiologist (ASA) I and II classes; no history of hypertension; no history of cerebrovascular accidents; no food allergy (especially to soya and egg); no history of acute porphyria Exclusion criteria: air way obstruction; laryngospasm; need to re-intubation after laryngoscope excitation; systolic blood pressure five minutes after induction of anesthesia less than 90 mmHg; surgery duration more than 30 minutes 17 years 80 years Both T88.5 Other complications of anaesthesia Treatment - Drugs Treatment - Drugs Treatment - Drugs Propofol, 2.2 mg/kg within 30 seconds; IV. Thiopental sodium, 5 mg/kg within 30 seconds; IV. Etomidate, 0.3 mg/kg within 30 seconds; IV. Diastolic blood pressure. Timepoint: Before and during intervention and after recovery time. 1, 3, 5, 10, 15 min after drug injection and 3, 5, 15, 30 min after recovery. Method of measurement: mm-Hg, sphygmomanometer. Systolic blood pressure. Timepoint: Before and during intervention and after recovery time. 1, 3, 5, 10, 15 min after drug injection and 3, 5, 15, 30 min after recovery. Method of measurement: mm-Hg, sphygmomanometer. Heart rate. Timepoint: Before and during intervention and after recovery time. 1, 3, 5, 10, 15 min after drug injection and 3, 5, 15, 30 min after recovery. Method of measurement: Electrocardiogram monitor. O2 saturation. Timepoint: Before and during intervention and after recovery time. 1, 3, 5, 10, 15 min after drug injection and 3, 5, 15, 30 min after recovery. Method of measurement: Pulseoxymeter. Surgeon's satisfaction of surgery. Timepoint: After the surgery. Method of measurement: Questionnaire. Time of surgery. Timepoint: Operation's time duration. Method of measurement: Timer. Time of recovery hospitalization. Timepoint: Recovery duration. Method of measurement: Timer. Mean arterial pressure. Timepoint: Before and during intervention and after recovery time. 1, 3, 5, 10, 15 min after drug injection and 3, 5, 15, 30 min after recovery. Method of measurement: mm-Hg, sphygmomanometer. Hypotension. Timepoint: Before and during intervention and after recovery time. 1, 3, 5, 10, 15 min after drug injection and 3, 5, 15, 30 min after recovery. Method of measurement: mm-Hg, sphygmomanometer. Tachycardia. Timepoint: Before and during intervention and after recovery time. 1, 3, 5, 10, 15 min after drug injection and 3, 5, 15, 30 min after recovery. Method of measurement: Electrocardiogram monitor. Hypertension. Timepoint: Before and during intervention and after recovery time. 1, 3, 5, 10, 15 min after drug injection and 3, 5, 15, 30 min after recovery. Method of measurement: mm-Hg, sphygmomanometer. Bradycardia. Timepoint: Before and during intervention and after recovery time. 1, 3, 5, 10, 15 min after drug injection and 3, 5, 15, 30 min after recovery. Method of measurement: Electrocardiogram monitor. Isfahan University of Medical Sciences Approved 2013-01-09 Isfahan University of Medical Sciences Isfahan University of Medical Sciences, Hezar jarib St. Isfahan Iran (Islamic Republic of)