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IRCT2015082622206N2 IRCT 2016-06-19 Vice Chancellor for Medical Sciences Research of Shiraz University Effect of Metoclopramide on fertility in women with loss of ovarian reserve Evaluation of the effect of dopamine D2 antagonist on the success of invitro fertilization in poor responders 2015-07-23 anticipated 50 Complete https://irct.ir/trial/19207 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A patients with poor ovarian response. Intervention 1: Interventional group: Metoclopramide 10 mg 4 times/day (pre prandial and at the bed side) The drug started 4 weeks before starting IVF cycle and continued till triggering with HCG. Intervention 2: Control group: similar placebo effect drugs with the same dose. (pre prandial and at the bed side) The drug started 4 weeks before starting IVF cycle and continued till triggering with HCG.
public Dr Pardis Bakhshaeie
Infertility Research Center Shiraz ,Fars ,Iran, Islamic Republic
Shiraz Iran (Islamic Republic of) +98 912 363 0119 Pardis.bakhshaie287@gmail.com Shiraz Unicversity of Medical Sciences scientific Dr Alamtaj Samsami
Infertility Research Center , Shiraz, Fars , Iran, Islamic Republic
Shiraz Iran (Islamic Republic of) +98 917 315 2795 Samsamia@sums.ac.ir, hafez_perina@sums.ac.ir Shiraz Univcersity of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: previous treatment using conventional protocols that yield less than 3 oocytes, abnormal ovarian reserve tests as AMH<0.5-1. 1ng/ml or AFC <5-7 Follicles, age over 40 years or any other risk factor that decrease the ovarian reserve such as previous ovarian surgery, genetic problems, chemotherapy, radiotherapy and autoimmune disease, having 2 or more of above factors (Bologna criteria). Exclusion criteria: not have above factors, no agreement of patient, she can not complete the coarse of treatment, become OHSS. (ovarian hyperstimulation syndrom) 40 years 50 years Female (P00-P96 Certain conditions originating in the perinatal period Treatment - Drugs Placebo Interventional group: Metoclopramide 10 mg 4 times/day (pre prandial and at the bed side) The drug started 4 weeks before starting IVF cycle and continued till triggering with HCG. Control group: similar placebo effect drugs with the same dose. (pre prandial and at the bed side) The drug started 4 weeks before starting IVF cycle and continued till triggering with HCG. Quality and number of ovum and embryo have received in each IVF cycle. Timepoint: On day of ovum pick up and embryo transfer. Method of measurement: Measuring number and quality of oocyte on the day of pick up in lab by embryologist under microscope (GV,MI,MII) and quality of embryo also by the same embryologist according to kind of cell division (grade I,II,III,IV). Clinical pregnancy or spontanous abortion. Timepoint: 7-12 weeks after embryo transfering. Method of measurement: Serum BHCG and TVS. Vice Chancellor for Medical Sciences Research of Shiraz University Approved 2015-07-12 Ethics committee Shiraz University Of Medical Science Building of Shiraz University Of Medical Science, Zand Street, Shiraz Shiraz Iran (Islamic Republic of)