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IRCT2015052122359N1 IRCT 2015-11-11 Vice chancellor for research,Shiraz University of Medical Sciences Comparison between oral and IV infusion of magnesium on arrhythmia and hypomagnesemia after heart surgery The Comparison between oral magnesium supplement before surgery and IV administration of magnesium during induction in prevention of hypomagnesemia and arrhythmia after coronary surgery in hospitals related to Shiraz University of Medical sciences 2015-04-21 anticipated 86 Complete https://irct.ir/trial/19297 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A Condition 1: Arrhythmia. Condition 2: hypomagnesemia. Intervention 1: Mg-so4 20% was given to the 43 patients in control group after anesthesia induction. Then during CPB, before rewarming take the blood sample and after opening cross clamp . 2gr Mgso4 inserted to the circuit.At the end of operation in ICU took another sample. Other samples have been taken after 6.12,24 and 48 hours after surgery. EKG-monitoring was done during these 2 days. Intervention 2: 20-30cc Mg- Hydroxide15% was given to the intervention group with NGT after anesthesia induction. Then during CPB, before rewarming take the blood sample and after opening cross clamp . 2gr Mgso4 20% inserted to the circuit.At the end of operation in ICU took another sample. Other samples have been taken after 6.12,24 and 48 hours after surgery. EKG-monitoring was done during these 2 days.
public Janati Mansor
Namazi hospital ,Namazi square .
Shiraz Iran (Islamic Republic of) +98 71 3647 4270 janatim@sums.ac.ir Shiraz University of Medical Sciences scientific Janati Mansor
Namazi hospital ,Namazi square .
Shiraz Iran (Islamic Republic of) +98 71 3647 4270 janatim@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria:All patients who are candidates for Coronary Artery Bypass Grafts in Shiraz University of Medical Sciences hospitals without Renal Failure, liver failure,no B- blocker or Ca- blocker preoperatively cause of arrhythmia, no preoperative Magnesium therapy . Exclusion criteria: Re-operation after main surgery because of hemorrhage, IABP usage . 40 years 99 years Both I20,I21,I2 E87.8 Ischaemic heart diseases Other disorders of electrolyte and fluid balance, not elsewhere classified Treatment - Drugs Treatment - Drugs Mg-so4 20% was given to the 43 patients in control group after anesthesia induction. Then during CPB, before rewarming take the blood sample and after opening cross clamp . 2gr Mgso4 inserted to the circuit.At the end of operation in ICU took another sample. Other samples have been taken after 6.12,24 and 48 hours after surgery. EKG-monitoring was done during these 2 days. 20-30cc Mg- Hydroxide15% was given to the intervention group with NGT after anesthesia induction. Then during CPB, before rewarming take the blood sample and after opening cross clamp . 2gr Mgso4 20% inserted to the circuit.At the end of operation in ICU took another sample. Other samples have been taken after 6.12,24 and 48 hours after surgery. EKG-monitoring was done during these 2 days. Serum magnesium level. Timepoint: pre operation,during cardiopulmonary bypass and 6,12,24,48 hours after CABG. Method of measurement: Serum Magnesium has been tested with dirui-cs800 set and with xylidyl blue test. Heart rhythm. Timepoint: 48 hours after CABG. Method of measurement: Heart monitoring. Vice chancellor for research,Shiraz University of Medical Sciences Approved 2015-05-24 Ethics committee of Shiraz University of Medical Sciences. Zand , St. Shiraz Iran (Islamic Republic of)