IRCT2015061422711N1 IRCT 2015-09-04 Tehran University of Medical Sciences Colon cancer screening in high-risk population Triple C (Colon Cancer Control) Trail Risk assessment counseling and screening in first degree relatives of colon cancer patients 2015-09-01 anticipated 280 Complete https://irct.ir/trial/19534 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Screening. N/A colorectal cancer. Intervention 1: Intervention includes below: • Tailored massages via phone counseling • Interactive and in-person counseling about screening barriers • Individualized motivational interview • Consequent Follow-up reminder calls. Intervention 2: One parallel control group of usual care will be designed in this study. That is, counselees (index patients or FDRs) in control group will receive a simple doctor recommendation that screening is necessary should be done in FDRs, and that they better to inform their FDRs, as happened in routine care, the main source of recommendation is doctor’s recommendation. Usually index patients during their treatment are informed by doctors about the risk of developing cancer in their relatives and the significance of screening or early detection among their relatives.