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IRCT20150622022869N6 IRCT 2018-02-07 Vice Chancellor for research of Yasuj University of Medical Sciences Effect of pentoxifylline on inflammatory and biochemical markers of hemodialysis patients Effect of pentoxifylline on inflammatory and biochemical markers of hemodialysis patients 2017-10-23 anticipated 50 Complete https://irct.ir/trial/19626 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random Permuted Blocks was used for randomization with blocks of size of 4 that after every 4 patients there was an equal number assigned to each treatment. For each block, one of the arrangements (CCII, CICI, ICCI, IICC, ICIC, CIIC) was randomly chosen(C= Control, I= Intervention). N/A End stage kidney disease. Intervention 1: Intervention: Pentoxifylline tablet 400 mg every nights for 3 month. Intervention 2: Control: usual supervision. Yes - There is a plan to make this available What will be shared: Some data such as major outcomes will be sharing. When: 1398 To whom: collegiate institution Conditions: only above instances Where to obtain: Valiollah Talebi valitalebi.md@gmail.com How to obtain: After sending e-mail Comments:
public Moslem Sedaghattalab
Emam Sajad hospital, Dr.Jalil street, Yasuj city
Yasuj Iran (Islamic Republic of) 75919-94579 +98 74 3322 0163 moslem.sedaghattalab@gmail.com Yasuj University of Medical Sciences scientific Moslem Sedaghattalab
Emam Sajad hospital, Dr.Jalil street, Yasuj city
Yasuj Iran (Islamic Republic of) 75919-94579 +98 74 3322 0163 moslem.sedaghattalab@gmail.com Yasuj University of Medical Sciences Iran (Islamic Republic of) Patients aged>18 years Patients who were dialysed at least three times per week for a 3 month period Presence of well vascular access Written and conscious satisfaction 18 years no limit Both Liver disease, malignancy, AIDS Patients who have active infectious disease in previous 2 month Allergy to pentoxifylline and other methylxanthines Kidney transplantation Blood disorders Cardiac arrhythmia Hypotention Taking NSAID and steroids Immune deficiency; Taking pentoxifylline in previous 3 month N18.5 Chronic kidney disease, stage 5 Treatment - Drugs N/A Intervention: Pentoxifylline tablet 400 mg every nights for 3 month Control: usual supervision IL-6. Timepoint: before intervention and 3 months after intervention. Method of measurement: ELISA. IL-10. Timepoint: before intervention and 3 months after intervention. Method of measurement: ELISA. TNF-α. Timepoint: before intervention and 3 months after intervention. Method of measurement: ELISA. CRP. Timepoint: before intervention and 3 months after intervention. Method of measurement: ELISA. Drug reaction. Timepoint: 3 months after intervention. Method of measurement: Questionnaire. Vice Chancellor for research of Yasuj University of Medical Sciences Approved 2016-08-04 Ethics Committee of Yasuj University of Medical Science Yasuj University of Medical Science, Motahari street, Yasuj city Yasuj Kohgilouyeh-va-Boyrahmad Iran (Islamic Republic of)