IRCT2015080323483N1 IRCT 2016-10-21 vice chancellor for research, Shiraz University of Medical Sciences The comparison of different types of fluid therapy in prevention of contrast induced renal malfunction in coronary angiography The comparison of normal saline, ringer lactate and sodium bicarbonate for prevention of contrast induced nephropathy in the patients who underwent coronary angiography in Shiraz 2015-07-23 anticipated 300 Complete https://irct.ir/trial/20024 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Other design features: In this study, both physician and patients were unaware of the nature of the therapy; therefore, it is considered as a double blind study. randomization method: for each patient, a code will be generated by using random-numbers table.If the ones of the code is (1,2,3) the patient will be placed in the first group (normal saline). If the ones of the code is (4,5,6) or (7,8,9) the patient will be categorized in the second (ringer lactate) and third group (sodium bicarbonate) respectively. In addition the codes with ones equal to zero will be deleted. N/A contrast induced nephropathy. Intervention 1: Intervention 1: In this group, the patients receive intravenous normal saline (0.9%) at a rate of 3 ml/kg one hour before angiography and 1 ml/kg per hour for 6 hours after angiography. Intervention 2: Intervention 2: In this group, the patients receive intravenous ringer lactate at rate of 3 ml/kg one hour before angiography and 1 ml/kg per hour for 6 hours after angiography. Intervention 3: Intervention 3: In this group, the patients receive intravenous sodium bicarbonate (850 ml DW 5% plus 150 mEq sodium bicarbonate) at a rate of 3 ml/kg one hour before angiography and 1 ml/kg per hour for 6 hours after angiography.