IRCT2017050723559N12 IRCT 2017-05-24 Vice chancellor for research, Ardabil University of Medical Sciences Changes of metabolism indexes and PTH in hemodialysis patients Comparison of treatment effect of active vitamin D versus passive vitamin D on bone metabolism indexes and PTH in hemodialysis patients 2017-07-23 anticipated 40 Complete https://irct.ir/trial/20082 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2 Condition 1: Disorders of mineral metabolism. Condition 2: Vitamin D deficiency. Condition 3: Chronic kidney disease. Condition 4: Abnormal levels of other serum enzymes. Intervention 1: Intervention group: Patients in intervention groupwill be divided into three groups based on serum levels of 25-hydroxy vitamin D (mild deficient: 16 – 20 ng/Ml , moderate deficient: 10 - 15 ng/Ml and severe deficient: < 10 ng/Ml), Then patients in mild deficient group will be received oral Rocaltrol capsule (0.25 µg every 24 hours produced by Osve CO) and oral cholecalciferol 50,000 units/week for 4 weeks (produced by Caspian tamin CO). Patients in moderate deficient group will be received oral Rocaltrol capsule every 24 hours and oral cholecalciferol 50,000 units/ every week for 8 weeks and patients in severe deficient group will be received oral Rocaltrol capsule every 24 hours and oral cholecalciferol 50,000 units/ every week for 12 weeks. Intervention 2: Control group: Patients in control group will be divided into three groups based on serum levels of 25-hydroxy vitamin D (mild deficient: 16 – 20 ng/Ml , moderate deficient: 10 - 15 ng/Ml and severe deficient: < 10 ng/Ml), Then patients in mild deficient group will be received oral Rocaltrol capsule (0.25 µg every24 hours produced by Osve CO) and oral Gelatin pearl every week for 4 weeks (produced by Caspian tamin CO). Patients in moderate deficient group will be received oral Rocaltrol capsule every 24 hours and oral Gelatin pearl every week for 8 weeks and patients in severe deficient group will be received oral Rocaltrol capsule every 24 hours and oral Gelatin pearl every week for 12 weeks.