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IRCT2015081323610N1 IRCT 2016-02-17 Vice Chancellor for research, Shahid Sadoughei University of Medical Sciences The effect of licorice syrup on dysmenorrhea The effect of licorice syrup on primary dysmenorrhea compared with Ibuprofen 2015-12-22 anticipated 60 Complete https://irct.ir/trial/20119 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: The mentioned scientific name has been registered unchanged as approved by the University Research Council. 3 Primary dysmenorrhea. Intervention 1: Intervention Group: licorice syrup at a dose of 5 mL twice daily and placebo every 8 hours during the first five days of each cycle and for two consecutive cycles. Intervention 2: Control Group: Ibuprofen 400 mg every 8 hours and 5 ml of placebo syrup twice a day, during the first five days of each cycle and for two consecutive cycles.
public zahra jafari
Imam Khomeini Ave.
Ardakan Iran (Islamic Republic of) +98 35 2723 8917 z-jafari@razi.tums.ac.ir Faculty of Traditional Medicine, Shahid Sadoughei University of Medical Sciences, Ardakan, Yazd scientific Dr. Majid Emtiazy
Imam Khomeini Ave.
Ardakan Iran (Islamic Republic of) +98 35 2723 8917 Dr.emtiazy@yahoo.com Faculty of Traditional Medicine, Shahid Sadoughei University of Medical Sciences, Ardakan, Yazd Iran (Islamic Republic of) Inclusion Criteria: Aged between 18-25 years; Moderate and severe dysmenorrhea (grade 2, 3) based on Verbal Multidimensional Scoring System; Regular menstrual cycles (every 21-35 days and bleeding 3 to 10 days for at least three recent cycles). Exclusion criteria: Pelvic pathology (including Endometriosis, Adenomyosis, Fibroids, Ovarian Cysts, Pelvic Inflammatory Disease, etc); Known diseases (including Chronic Hepatitis, Cholestatic Liver Disease, Cirrhosis, Severe Renal Insufficiency, Diabetes Mellitus, Arrhythmias, Hypertension, Hypertonia and Hypokalemia); Existence of stressors (such as loss of a close relative and Intense familial debate) during recent 6 months; History of allergy to licorice; Concurrent use of other products containing licorice; Taking another painkiller that is not defined in the study; Concomitant use of OCP; Drug intolerance; Lack of desire to continue the treatment for any reason; Another disease that will have required medical treatment during the study. 18 years 25 years Female N94.4 Primary dysmenorrhea Treatment - Drugs Treatment - Drugs Intervention Group: licorice syrup at a dose of 5 mL twice daily and placebo every 8 hours during the first five days of each cycle and for two consecutive cycles Control Group: Ibuprofen 400 mg every 8 hours and 5 ml of placebo syrup twice a day, during the first five days of each cycle and for two consecutive cycles Pain intensity. Timepoint: Before intervention- Every day during intervention. Method of measurement: Visual Analogue Scale(VAS). Pain duration. Timepoint: Before intervention- Every day during intervention. Method of measurement: hour. Adverse effect of licorice syrup. Timepoint: At the end of each cycle of intervention. Method of measurement: Questionnaire. Adverse effect of Ibuprofen such as Nausea, dyspepsia, vomiting, ulcers and gastrointestinal bleeding. Timepoint: At the end of each cycle of intervention. Method of measurement: Questionnaire. Vice Chancellor for research, Shahid Sadoughei University of Medical Sciences Approved 2015-11-30 Ethics committee of Shahid Sadoughi University of Medical Sciences Central department of Shahid Sadoughi University of Medical Sciences, Shahid Bahonar Sq. Yazd Iran (Islamic Republic of)