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IRCT2015081623645N1 IRCT 2015-12-13 Vice chancellor for research, Ahvaz Jundishapour University of Medical Sciences Effect of astaxanthin intake in patients affected by type 2 diabetes mellitus Effect of Astaxanthin intake on expression of miR-146a and miR-126 in plasma, oxidative stress and inflammation markers and glycemic profile, compared with placebo in patients with type 2 diabetes mellitus 2015-10-07 anticipated 48 Complete https://irct.ir/trial/20153 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 0 (exploratory trials) Diabetes. Intervention 1: Using of food supplement contain 8 mg of Astaxanthin daily orally for 8-weeks Made in USA. Intervention 2: Use of a placebo pill containing starch and manufacture by Faculty of Pharmacy of Ahvaz Jundishapur University of Medical Sciences for 8-weeks.
public Nafiseh Shokri
Dept of Nutrition, School of Paramedical, Ahvaz Jundishapur University of Medical Science,Golestan Ave, Ahvaz,Khouzestan
Ahvaz Iran (Islamic Republic of) +98 61 3373 8330 nafiseh.shokri@yahoo.com , shokri.n@ajums.ac.ir Ahvaz Jundishapour University of Medical Sciences scientific Majid Mohammad Shahi
Dept of Nutrition, School of Paramedical, Ahvaz Jundishapur University of Medical Science,Golestan Ave, Ahvaz,Khouzestan
Ahvaz Iran (Islamic Republic of) +98 61 3373 8330 shahi334@gmail.com Ahvaz Jundishapur University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Willingness to participate in the study, age range between 30-60 years old, Body Mass Index range between 19 and 35 kg per m2, HbA1C more than seven, not to be affected by renal, liver, lung and autoimmune disease, normal thyroid status, patients who have received standard oral treatments for at least six months. Exclusion criteria:Failure to follow the study 30 years 60 years Both E11,E12 Non-insulin-dependent diabetes mellitus, Malnutrition-related diabetes mellitus Treatment - Drugs Placebo Using of food supplement contain 8 mg of Astaxanthin daily orally for 8-weeks Made in USA Use of a placebo pill containing starch and manufacture by Faculty of Pharmacy of Ahvaz Jundishapur University of Medical Sciences for 8-weeks FBS. Timepoint: at first and two months after intervention. Method of measurement: glucose enzymatic kit. Fructosamine. Timepoint: at first and two months after intervention. Method of measurement: ELISA. HDL. Timepoint: at first and two months after intervention. Method of measurement: spectrophotometer. LDL. Timepoint: at first and two months after intervention. Method of measurement: spectrophotometer. TG. Timepoint: at first and two months after intervention. Method of measurement: spectrophotometer. IL6. Timepoint: at first and two months after intervention. Method of measurement: Elisa kit. Adiponectin. Timepoint: at first and 2 months after intervention. Method of measurement: ELISA. MDA. Timepoint: at first and two months after intervention. Method of measurement: TBARS. Vice chancellor for research, Ahvaz Jundishapour University of Medical Sciences Approved 2015-07-25 Ethics Committee of Ahvaz Jundishapur University of Medical Sciences Khuozestan, Ahvaz, Ahvaz Jundishapur University of Medical Sciences, Ethics Committee Ahvaz Iran (Islamic Republic of)