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IRCT2015090723927N1 IRCT 2015-11-02 Vice chancellor for research,Tabriz university of medical science. Sertraline effectiveness in prevention of depression in MS patients. Sertraline effectiveness in prevention of depression, fatigue reduction and QOL improvement in MS patients. 2015-09-21 anticipated 60 Complete https://irct.ir/trial/20319 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 2-3 Multiple sclerosis. Intervention 1: In study group we will add 50 mg sertraline produced by sobhan manufacture every day for six months,this group will consider at the beginning ,end of 1th month, 3th month and end 6th month for depression symptoms. Intervention 2: In control group we will add one placebo produced by pharmacy faculty of Tabriz university of medical science for six months every day . They will consider at the beginning , end of 1th month ,3th month and end of 6th month.
public Mohammad Askarpour
Tabriz university of medical scince, Golgasht Av, Tabriz, Iran
Tabriz Iran (Islamic Republic of) +98 41 3336 4667 info@medfac.tbzmed.ac.ir Tabriz university of medical science scientific Sepideh Herizchi Ghadim
Tabriz university of medical science,Golgasht Ave,Tabriz, Iran
Tabriz Iran (Islamic Republic of) +98 41 3335 5921 http://mail.tbzmed.ac.ir/ Tabriz University Of Medical Scienve Iran (Islamic Republic of) Inclusion Criteria: Age 15-60;Primary education Exclusion; Other Organic illnesses:Other mental disorder;Smoking and substance induce or alcohol abuser. 79 years 34 years Both G35 Multiple sclerosis Prevention Placebo In study group we will add 50 mg sertraline produced by sobhan manufacture every day for six months,this group will consider at the beginning ,end of 1th month, 3th month and end 6th month for depression symptoms. In control group we will add one placebo produced by pharmacy faculty of Tabriz university of medical science for six months every day . They will consider at the beginning , end of 1th month ,3th month and end of 6th month. Depresion. Timepoint: Atfirst of study, 1 mth later, 3mth later, 6 mth later. Method of measurement: Hamilton Questionnaire. Decreament OF Fatigue. Timepoint: Atfirst of study, 1 mth later, 3mth later, 6 mth later. Method of measurement: SF_36 Questionnaire. Quality of life. Timepoint: Atfirst of study, 1 mth later, 3mth later, 6 mth later. Method of measurement: FSS Questionnaire OF QOL. Probably switch to mania. Timepoint: During fallow up times. Method of measurement: Based on DSM criteria. -------- ------ -------- ------------ Vice chancellor for research,Tabriz university of medical science. Approved 2015-09-02 Ethics committee of Tabriz university of medical sciences Flour 3, Building 2, Golgasht Av, Tabriz university of medical science Tabriz Iran (Islamic Republic of)