IRCT20150909023957N7 IRCT 2018-12-18 Vice Chancellor for Research, Isfahan University of Medical Sciences Effect of low calorie diets on inflammation in metabolic syndrome Effect of Modified Alternate-Day Fasting (ADF) in contrast with Calorie Restriction (CR) on inflammatory index and coagulation factors in metabolic syndrome patients. 2017-07-06 anticipated 70 Complete https://irct.ir/trial/20339 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: All participants were stratified for body mass index (BMI), age and sex, and were randomly assigned to ADF or CR group for 8 weeks. Randomization was performed using by random-generation software. N/A metabolic syndrome disease. Intervention 1: During 8-week ADF period, subjects consumed very low calorie diet (75% energy restriction) during the 3 fast days (Saturday, Monday, Wednesday) and then ate diet that providing 100% of their energy needs on each feed day (3 days a week). In Friday subjects consumed ad libitum without limitation. ADF subjects were provided with meals on each fast day (ranging from 400-600 kcal), and consumed ad libitum at home on the feed day. The feed and fast days began at midnight each day, and all fast day meals were consumed between 12.00 pm and 2.00 pm to ensure that each subject was undergoing the same duration of fasting All foods were prepared in the home. Subjects were permitted to consume calorie- free foods such as water, tea, green tea, coffee without sugar (< 400 mg caffeine per day), non-starchy vegetable (such as lettuce, cucumberو tomato) and sugar free gums on the fast day and were encouraged to drink plenty of water. Intervention 2: Control group: In Calorie Restriction group, subjects consumed 75% energy needs in each day for 8 weeks and includes 3 main meals and 2 snacks. All subjects in two groups were required to prepare all of their meals at home. The baseline energy requirements for the subjects were assessed by Mifflin equation. Daily dietary carbohydrate, fat and protein accounted for 52, 30 and 18% of ingested energy, respectively. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information