]>
IRCT2015092824236N1 IRCT 2016-07-09 Vice Chancellor for Research of Shahid Sadoughi University of Medical Sciences The effect of Donepezil on Depression The effect of Donepezil on cognitive disturbances due to Selective Serotonine reuotake Inhibitor drugs in major Depressive disorders 2014-06-22 anticipated 76 Complete https://irct.ir/trial/20507 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 3 Majore Depressive. Intervention 1: Intervention group: Donepezil 0.5 mg tablet daily for 2 months. Intervention 2: In the control group: Placebo Donepezil daily for 2 months.
public Amir Houshang Mehrparvar
Yazd Shahid Sadoughi University of Medical Sciences, Bahonar Sq, Yazd
Yazd Iran (Islamic Republic of) +98 35 3726 3733 ahmehrparvar@ssu.ac.ir Yazd Shahid Sadoughi University of Medical Sciences scientific Fatemeh Hosseini
Mental Hospital, Yazd Shahid Sadoughi University of Medical Sciences
Yazd Iran (Islamic Republic of) +98 35 3263 2005 hosseini.k.f@gmail.com Yazd Shahid Sadoughi University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: Patients in the age range 30 to 40 years, Complete the consent form, with major Depression according to the text of the revised fourth edition of Diagnostic and Statistical Manual of Mental Disorders, Treated with selective Serotonin reuptake inhibitors, Two months after receiving Antidepressant assessment exam Montreal is less than 26. Exclusion criteria: At the same time suffering from major Depression and other mental disorders. At the same time suffering from major Depression and a physical disorder with features of cognitive impairment including Alzheimer or other degenerative neurological disorders, head injuries or Hypothyroidism. Concomitant use of Anticholinergic agents and nervous system Depressant drugs 30 years 40 years Both F32.3 Severe depressive episode with psychotic symptoms Treatment - Drugs Treatment - Drugs Intervention group: Donepezil 0.5 mg tablet daily for 2 months In the control group: Placebo Donepezil daily for 2 months Major Depressive Disorder. Timepoint: 2 months after drug consumption. Method of measurement: Montreal Cognitive assessment test. Drug side effects. Timepoint: 2 months after drug consumption. Method of measurement: Examination and test results. Vice Chancellor for Research of Shahid Sadoughi University of Medical Sciences Approved 2015-05-22 Ethic Committee of Shahid Sadoughi University of Medical Sciences Shahid Sadoughi University of Medical Sciences, Bahonar Sq, Yazd Yazd Iran (Islamic Republic of)