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IRCT2015101224490N1 IRCT 2016-05-03 Vice chancellor for research of Mazandaran University of Medical Sciences Assessing the effectiveness of Aloe vera 2% gel in treatment of Cutaneous Leishmaniasis (CL) on the base of Traditional Persian Medicine (TPM) Assessing the effectiveness of Aloe vera 2% gel in treatment of Cutaneous Leishmaniasis (CL) on the base of Traditional Persian Medicine (TPM) 2015-11-01 anticipated 90 Complete https://irct.ir/trial/20657 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization will be performed by using the random number tables. N/A cutaneous leishmaniasis. Intervention 1: Intervention group: Aloe vera 2% Gel two times a day a layer until the full lesion epithelialization or up to 4 weeks after last intervention. Intervention 2: Control group: Placebo Gel two times a day a layer until the full lesion epithelialization or up to 4 weeks after last intervention.
public Omid Mozafari
Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences
Sari Iran (Islamic Republic of) 497164885 +98 11 3324 4893 dr.mozafari@goums.ac.ir Mazandaran University of Medical Sciences scientific Syde Sedighe Yosefi
Imam square, Joybar threeway, start of Valiye Asr highway, Sari
Sari Iran (Islamic Republic of) +98 11 3324 4893 dr_ssyosefi@yahoo.com Mazandaran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patients with lesions which lasts more than 14 days and definitely diagnosed cutaneous leishmaniasis by parasites seen in smears taken from skin lesions, and treating by the national standard treatment guidelines, after complete description of the study, in the case of consent to participate in the study areŘ› Exclusion criteria: pregnant women, patients with allergy to antimuan, patients taking more than three months have passed since the first appearance of skin lesions, patients in recent months any way be used to treat leishmaniasis, patients which their wound on the eyelids, ear, nose or are less than one centimeter is near the end of the lips and eyes no limit no limit Both B55.1 Cutaneous leishmaniasis Treatment - Drugs Placebo Intervention group: Aloe vera 2% Gel two times a day a layer until the full lesion epithelialization or up to 4 weeks after last intervention Control group: Placebo Gel two times a day a layer until the full lesion epithelialization or up to 4 weeks after last intervention Longest diameter of ulceration area. Timepoint: 0,7,14,21,28 day& if not cured 4 week after last intervention. Method of measurement: ruler. Longest diameter of Induration area. Timepoint: 0,7,14,21,28 day& if not cured 4 week after last intervention. Method of measurement: ruler. Healing rate. Timepoint: 0,7,14,21,28 day& if not cured 4 week after last intervention. Method of measurement: observation & calculation. Treatment resualt. Timepoint: at the end of treatmen, and if lesion not full epithelialized 4 weeks after last intervention. Method of measurement: observation & determination. Side effect. Timepoint: during treatment. Method of measurement: observation & interview. Vice chancellor for research of Mazandaran University of Medical Sciences Approved 2015-09-30 Ethics committee of Mazandaran University of Medical Sciences Imam square, Joybar threeway, start of Valiye Asr highway, Sari Sari Iran (Islamic Republic of)