IRCT2015101924601N1 IRCT 2015-11-29 Vice Chancellor for Research of Ardabil University of Medical Sciences The effect of tranexamic acid on reducing of bleeding during spinal fixation surgery Comparison of two doses of tranexamic acid on reducing of bleeding during spinal fusion surgery 2015-11-06 anticipated 102 Complete https://irct.ir/trial/20727 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A The effect of two different form Tranexamic Acid administration for bleeding reduction at spinal fixation surgery. Intervention 1: Infusion 10 mg/kg of tranexamic acid by microset with total volume of 100 cc during 10 minutes before skin incision and continued with 20 drop/ min of normal saline as placebo. Intervention 2: Infusion 10 mg/kg of tranexamic acid by microset with total volume of 100 cc during 10 minutes before skin incision and continued by 1 mg/kg/hour drug infusion untill end of surgery. Intervention 3: control group: infusion of 100 cc normal saline during 10 minutes and continued infusion with 20 drop/min untill end of suegery as placebo.