IRCT138809242405N3 IRCT 2010-01-20 Isfahan University of Medical Sciences Evaluating the Effect of Subcutaneous Dexamethasone Added to Bupivacaine on Postcesarean Pain Relief Evaluating the Effect of Subcutaneous Dexamethasone Added to Bupivacaine on Postcesarean Pain Relief 2008-07-29 anticipated 75 Complete https://irct.ir/trial/2100 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 4 Complications of anaesthesia during pregnancy. Intervention 1: bupivacaine 20 ml,0.25% (SC) + dexamethasone 4 ml (16 mg) (SC) +Normal saline 4 ml iv, Duration of treatment: single dose . Intervention 2: bupivacaine 20 ml,0.25%(SC) + dexamethasone 4 ml (16 mg) iv+ Normal saline 4 ml iv, Duration of treatment: single dose . Intervention 3: bupivacaine 20 ml,0.25% (SC) + normal saline 4 ml SC+ normal saline 4 ml iv (placebo group). Duration of treatment: single dose .

public Ms. Leila Bakhshi

Research Brueae, Medical School, Hezar Jarib St. , Isfahan University of Medical Sciences

Isfahan Iran (Islamic Republic of) +98 31 1792 2269 jabalameli@med.mui.ac.ir Research Brueae, Medical School, Isfahan University of Medical Sciences scientific Dr. Mitra Jabalameli

Department of Anesthesia and intensive care, Alzahra General Hospital, sofe Boulevard

Isfahan Iran (Islamic Republic of) +98 31 1625 5555 jabalameli@med.mui.ac.ir Isfahan University of Medical Sciences Iran (Islamic Republic of) Inclusion Criteria: Parturients, ASA physical status I-II, scheduled for elective cesarean section, under general anesthesia. Exclusion Criteria: patients with suspected or manifest bleeding disturbances, allergy to Bupivacaine or Dexamethasone, atopia, diabetes mellitus, the presence of liver or kidney diseases, abuse of drugs and patients with pregnant induced hypertension or preeclampsia. 16 years 45 years Female O29.8 Other complications of anaesthesia during pregnancy Treatment - Drugs Treatment - Drugs Treatment - Drugs bupivacaine 20 ml,0.25% (SC) + dexamethasone 4 ml (16 mg) (SC) +Normal saline 4 ml iv, Duration of treatment: single dose . bupivacaine 20 ml,0.25%(SC) + dexamethasone 4 ml (16 mg) iv+ Normal saline 4 ml iv, Duration of treatment: single dose . bupivacaine 20 ml,0.25% (SC) + normal saline 4 ml SC+ normal saline 4 ml iv (placebo group). Duration of treatment: single dose . Pain intensity. Timepoint: recovery room ,6 , 12, 24, 48 and 72 hours postoperative. Method of measurement: Visual Analogous Scale (VAS) and scoring from 0 to 10. Systolic blood pressure. Timepoint: at recovery room ,6 , 12, 24, 48 and 72 hours postoperative. Method of measurement: using mercury manometer. Diastolic blood pressure. Timepoint: at recovery room ,6 , 12, 24, 48 and 72 hours postoperative. Method of measurement: using mercury manometer. Opioid consumption. Timepoint: at recovery room ,6 , 12, 24, 48 and 72 hours postoperative. Method of measurement: mili gram of opioid. Heart rate. Timepoint: at recovery room ,6 , 12, 24, 48 and 72 hours postoperative. Method of measurement: Using EKG Monitoring. Isfahan University of Medical Sciences Approved 2007-04-21 Isfahan University of Medical Sciences Research Brueae, Isfahan University of Medical Sciences Isfahan Iran (Islamic Republic of)