IRCT2015111825123N1 IRCT 2016-12-08 Vice chancellor for research Shahid Sadoughi University of medical sciences Effect of hyoscine on severity of pain, tenderness and rebound tenderness in patients candidate for appendectomy Effect of hyoscine on severity of pain, tenderness and rebound tenderness in patients candidate for appendectomy 2015-03-21 anticipated 70 Complete https://irct.ir/trial/21062 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Supportive, Other design features: This interventional study (before-after) was conducted on 70 patients who were candidates for appendicitis surgery and referred to Shahid Sadoughi and Farokhi hospitals, Yazd, Iran. The patients were selected in a non random manner. No placebo group was considered since there was no expectation to reduce the pain without analgesics. Inclusion criteria of the current study were as follows: taking any psychiatric medicine, lesions on the abdominal surface such as cellulite, scars, taking analgesic drugs before entering the emergency room, hiatal hernia, history of kidney stones, current urinary infection, history of trauma on the area during last 2 weeks, menstrual bleeding, drug addiction. Sensitivity to drug was considered as exclusion criterion. First demographic information such as age and sex was obtained. To establish appendicitis diagnosis of surgery candidates, patients’ rebound tenderness and pain were evaluated usingnumeric rating scale. Then 0.3 mg /kg of hyoscine was administered intravenously. Using the previous method, rebound tenderness and pain were remeasured fifteen minutes later. Regarding the possibility of negative appendectomy or other diagnoses, 70 patients diagnosed with appendicitis by pathologist were underwent further investigation. N/A Pain in appendicitis. 0.3 mg /kg of hyoscine (Matin co- Tehran pharmacology) was administered intravenously. Using the previous method, rebound tenderness and pain were measured fifteen minutes later..