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IRCT138806112406N1 IRCT 2010-01-27 Research managment center of Bushehr University of Medical Sciences Therapeutic effect of oral NAC on Sinusitis Evaluation of therapeutic effect of oral N-Acetyl Cystein in comparison with placebo in patients diagnosed as subacute sinusitis, a double blind placebo controlled randomized clinical trial 2008-11-19 anticipated 45 Complete https://irct.ir/trial/2108 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 3 subacute Sinusitis. Intervention 1: Co-Amoxiclav (Amoxicillin 500 mg and Clavulanic acid 125mg Q8h, orally), pseudoephedrine (60mg three times a day, orally), and Sodium chloride irrigation plus N-Acetyl Cysteine (6oo mg, three times a day, orally) for two weeks. Intervention 2: Co-Amoxiclav (Amoxicillin 500 mg and Clavulanic acid 125mg Q8h, orally), pseudoephedrine (60mg three times a day, orally), and Sodium chloride irrigation plus placebo.
public Dr. Gholam_Hosein Monavvar_Sadegh
Medical Faculty, Bushehr University of Medical Sciences, Moallem street
Bushehr Iran (Islamic Republic of) +98 77 1252 4044 dr.monavarsadegh@yahoo.com Bushehr University of Medical Sciences scientific Dr. Mehrzad Bahtouee
Medical Faculty, Bushehr University of Medical Sciences, Moallem street
Bushehr Iran (Islamic Republic of) +98 77 1252 4044 mbahtouee@bpums.ac.ir Bushehr University of Medical Sciences, Medical Faculty Iran (Islamic Republic of) Inclusion criteria: Presence of subacute sinusitis according to signs and symptoms 3 weeks to 3 months and signs of sinusitis in CT scan Exclusion criteria: Presence of allergic rhinitis, asthma, pregnancy, diabetes mellitus, transplantation, CRF, chronic alcoholism, severe malnutrition, AIDS, Down syndrome, history of migraine, HTN, BPH, consumption of antidepressants, Methyl dopa, Propranolol, or Warfarin, history of kidney stone, or liver disease, more than 60 years old age, drivers, or pilots 18 years 60 years Both Treatment - Drugs Treatment - Drugs Co-Amoxiclav (Amoxicillin 500 mg and Clavulanic acid 125mg Q8h, orally), pseudoephedrine (60mg three times a day, orally), and Sodium chloride irrigation plus N-Acetyl Cysteine (6oo mg, three times a day, orally) for two weeks. Co-Amoxiclav (Amoxicillin 500 mg and Clavulanic acid 125mg Q8h, orally), pseudoephedrine (60mg three times a day, orally), and Sodium chloride irrigation plus placebo. Culture of nasal secretion. Timepoint: 1 month after competement of treatment. Method of measurement: microbiological culture. Signs and symptoms of disease. Timepoint: 1 day after completement of treatment. Method of measurement: face to face completement of Snot 20 questionnaire by a physician. Involvement of paranasal sinuses. Timepoint: 1 month after competement of treatment. Method of measurement: CT scan, cure rate of sinusitis according to Lund-Mackay score. Clinical improvement. Timepoint: 1 day and one month after copletement of treatment. Method of measurement: snot20 questionaire. Radiological improvement in paranasal CT scan. Timepoint: 1 month after completment of treatment. Method of measurement: Lund-Mackey score. Research managment center of Bushehr University of Medical Sciences Approved 2010-06-10 Research managment center, Bushehr University of Medical Sciences Research managment center, Bushehr University of Medical Sciences, Moallem street, Bushehr Bushehr Iran (Islamic Republic of)