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IRCT2015120425245N2 IRCT 2015-12-30 for research of Yazd Shahid Sadoughi University of Medical Sciences The effect of L- arginine supplementation on metabolic syndrome. The effect of L- arginine supplementation on the lipid profile, glycemic index and insulin resistance in patients with metabolic syndrome. 2015-12-01 anticipated 60 Complete https://irct.ir/trial/21139 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Metabolic Syndrome. Intervention 1: Intervention group: received two 2500 mg sachet arginine Production of pharmaceutical company Karen after lunch and dinner. Intervention 2: Control group: received 2500 mg sachet containing cellulose compounds Production of pharmaceutical company Karen after lunch and dinner.
public Davood Bahrami
Graduate Units,Department of Health,Shahid Sadoughi University of Medical Sciences, Hesabi Blvd
Yazd Iran (Islamic Republic of) 8915173143 +98 35338209114 davud.bahrami@gmail.com Yazd Shahid Sadoughi University of Medical Sciences scientific Hasan Mozaffari Khosravi
Graduate Units,Department of Health,Shahid Sadoughi University of Medical Sciences, Hesabi Blvd
Yazd Iran (Islamic Republic of) +98 35338209114 mozaffari.kh@gmail.com Yazd Shahid Sadughi University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Patients who agree to participate in the study؛ Having 3 or more of the ATP III criteria؛ Aged between 20 to 60. Exclusion criteria: The unwillingness of people to enter the study for any reason؛ Tobacco and alcohol؛ BMI above 35 and below 18.5؛ Pregnancy and lactationv hypersensitivity to the drug or allergy,Follow the special dietary؛ the use of insulin and Inflammatory drugs such as corticosteroids over 3 months؛ History of diabetes are more than 5 yearsv History of angina؛ stroke or heart attack in recent years؛ Chronic kidney disease or severe liver disease؛ Chronic inflammatory disease and thyroid disease during the past year؛ Taking any dietary supplement including L- arginine during 2 months before the start of the study. 20 years 60 years Both - - Placebo Placebo Intervention group: received two 2500 mg sachet arginine Production of pharmaceutical company Karen after lunch and dinner Control group: received 2500 mg sachet containing cellulose compounds Production of pharmaceutical company Karen after lunch and dinner Fasting blood sugar. Timepoint: at the begining of the study and 3 month after intervention. Method of measurement: Autoanalaizer. HBA1C. Timepoint: at the begining of the study and 3 month after intervention. Method of measurement: Enzyme colorimetry. Total Cholesterol. Timepoint: at the begining of the study and 3 month after intervention. Method of measurement: Enzyme colorimetry. LDL. Timepoint: at the begining of the study and 3 month after intervention. Method of measurement: Enzyme colorimetry. HDL. Timepoint: at the begining of the study and 3 month after intervention. Method of measurement: Enzyme colorimetry. TG. Timepoint: at the begining of the study and 3 month after intervention. Method of measurement: Enzyme colorimetry. INSULIN. Timepoint: at the begining of the study and 3 month after intervention. Method of measurement: Enzyme colorimetry. HOMA-IR. Timepoint: at the begining of the study and 3 month after intervention. Method of measurement: Using insulin and fasting glucose. HOMA-B. Timepoint: at the begining of the study and 3 month after intervention. Method of measurement: Using insulin and fasting glucose. QUICKI. Timepoint: at the begining of the study and 3 month after intervention. Method of measurement: Using insulin and fasting glucose. for research of Yazd Shahid Sadoughi University of Medical Sciences Approved 2015-11-14 Ethics committee of Yazd Shahid Sadoughi University of Medical Sciences Department of Health, Yazd Shahid Sadoughi University of Medical Sciences Yazd Iran (Islamic Republic of)