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IRCT201101012417N6 IRCT 2011-01-13 Vice Chancellor for Research, Isfahan University of Medical Sciences Effect of pentoxyphilin on reducing erythropoietin needs in peritoneal dialysis patiente with anemia Effect of pentoxyphilin on reducing erythropoietin needs in peritoneal dialysis patiente with anemia 2009-04-04 anticipated 50 Complete https://irct.ir/trial/2117 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A End Stage Renal Disease. Intervention 1: Pentoxyphylin, 400mg orally daily for 6 months. Intervention 2: Placebo daily for 6 months orally.
public Dr. Mojgan Mortazavi
Isfahan University of Medical Sciences
Isfahan Iran (Islamic Republic of) +98 31 1668 5555 m_mortazavi@med.mui.ac.ir Isfahan University of Medical Science scientific Dr. Mojgan Mortazavi
Isfahan University of Medical Sciences
Isfahan Iran (Islamic Republic of) +98 31 1668 5555 m_mortazavi@med.mui.ac.ir Isfahan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patient’s satisfaction, hemodialysis for at least 1 month prior to the study, hemoglobin concentration less than 10g/dL in at least 2 episodes, Erythropoietin use more than 12000 units per week, no bleeding over the last month prior to the intervention, no infection resulting admission over the last month prior to the intervention, vitamin C consumption 250mg twice a week Exclusion criteria: drug intolerance, bleeding during the study period, infection resulting admission 18 years 90 years Both N18.0 End-stage renal disease Treatment - Drugs Placebo Pentoxyphylin, 400mg orally daily for 6 months Placebo daily for 6 months orally Serum hemoglobin level. Timepoint: Baseline, monthly, at the end of the study. Method of measurement: g/dL. Serum albumin. Timepoint: Baseline, monthly, at the end of the study. Method of measurement: g/dL. Erythropoietin use. Timepoint: monthly. Method of measurement: International unit. Serum Iron level. Timepoint: Baseline, 3rd month, at the end of study. Method of measurement: µg/dL. Total iron binding capacity. Timepoint: Baseline, 3rd month, at the end of study. Method of measurement: µg/dL. Vice Chancellor for Research, Isfahan University of Medical Sciences Approved 2010-02-20 Vice Chancellor for Research, Isfahan University of Medical Sciences Isfahan 1000 jarib Isfahan Iran (Islamic Republic of)