]>
IRCT2015120825439N1 IRCT 2016-02-21 Birjand University of Medica Sciences Efficacy of zincsulfate in icter Efficacy of zinc sulfate in reducing unconjugated hyperbilirubinemia in premature neonate in NICU 2015-03-20 anticipated 60 Complete https://irct.ir/trial/21277 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A indirect hyperbilirubinemia. Intervention 1: all of neonate will treat with photothrapy.neonate in sulfate group reciecive 1mg/kg (5mg/5cc)zincsulfate more than photo.prescription is oral with syrang and every 6 hours until the end of phototherapy.measurment of the level of bilirubin is the bigining of admission then 6 hours after that and then daily. Intervention 2: In control group neonatewill recieve 1mg/kg placebo(sucrose) more than photo.prescription is oral with syrang and every 6 hours until the end of phototherapy.measurment of the level of bilirubin is the bigining of admission then 6 hours after that and then daily ,. Abstract<br /> Introduction and Aim: Ichter and hyperbilirubinemia are common and, in most cases, benign problems in infancy. Ichter occurs in about 60% of the term and 80% of preterm infants during the first weeks of life. Several studies conducted on the impact of zinc salts on indirect serum bilirubin levels in newborns have shown different results, all of which have called for further research. The aim of this study was to determine the effect of zinc sulfate on indirect hyperbilirubinemia in premature infants admitted to the NICU.<br /> Materials and methods: As a randomized, double-blind, clinical trial, this study was conducted in the NICU of Vali-e-Asr Hospital. The population consisted of premature infants admitted to the NICU of Vali-e-Asr Hospital. The sample included 60 infants who were randomly assigned into intervention and control groups (n=30 per group). While both groups underwent phototherapy, the intervention group received 1 cc/kg zinc sulfate syrup (containing 5 mg/5cc zinc sulfate) whereas the control group was given 2 cc/kg placebo syrup (containing sucrose) simultaneously. Assessment was made at the time of hospitalization, 6 hours later, and on a daily basis. The data were analyzed in SPSS software (version 21) using descriptive (mean, standard deviation, frequency and percentage) and inferential statistical tests (independent t-test, ANOVA, post hoc Bonferroni test, and Mann-Whitney test). P values less than or equal to 0.05 were considered significant.<br /> Findings: The study included 30 infants in the intervention group and 30 infants in the control group. There were not significant differences between the two groups in terms of gender, mean birth age at the start of phototherapy, and gestational age. Changes in bilirubin levels, respectively in intervention and control groups, 6 hours after treatment were -1.45±3.23 and -0.49±0.37 (P=0.024): at 24 hours, -3.26±2.78 and -1.89±1.20 (P0.017); and at 48 hours, -4.89±2.76 and -3.98±2.32 (P=0.23). Phototherapy time had no significant difference between the two groups (P=0.24).<br /> Conclusion: The results of this study showed that application of zinc sulfate syrup in premature infants with indirect hyperbilirubinemia within 48 hours of starting treatment could substantially reduce bilirubin levels.<br /> Key Words: Ichter; Premature Infants; Zinc Sulfate<br />
public Gholamreza Faal
Valiasr Hospital
Birjand Iran (Islamic Republic of) +98 56 3244 3005 grfal@yahoo.com Birjand University of Medical Sciences scientific Gholam Reza Faal
Ghafari aveniue
Birjand Iran (Islamic Republic of) +98 56 3244 3005 grfal@yahoo.com Birjand University of Medical Uciences Iran (Islamic Republic of) inclusion criteria:premature neonate with GA30-37week;weight1500-2500 exclusion criteria:hemolysis; o sepsis;abnormality;dehydration;G6PD;ABOmissmatch;positive coombs;history of consumption phenobarbital by mother;IUGR;ventilation;NPO no limit 1 month Both P59.0 Neonatal jaundice associated with preterm delivery Treatment - Drugs Placebo all of neonate will treat with photothrapy.neonate in sulfate group reciecive 1mg/kg (5mg/5cc)zincsulfate more than photo.prescription is oral with syrang and every 6 hours until the end of phototherapy.measurment of the level of bilirubin is the bigining of admission then 6 hours after that and then daily In control group neonatewill recieve 1mg/kg placebo(sucrose) more than photo.prescription is oral with syrang and every 6 hours until the end of phototherapy.measurment of the level of bilirubin is the bigining of admission then 6 hours after that and then daily , Level of bilirubin. Timepoint: 6hours/24hours/48hours. Method of measurement: mg/dl. Time of phototherapy. Timepoint: 6hours/24hours/48hours. Method of measurement: hour. Birjand University of Medica Sciences Approved 2015-10-31 Birjand University of Medical Sciences ghafari aveniue Birjand Iran (Islamic Republic of)