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IRCT2015121225481N1 IRCT 2016-02-26 Vice Chancellor for research of Mashhad University of Medical Sciences Investigation the effect of dextrose saline on the reduction of post operation nausea and vomiting (PONV) Investigation of the effects of dextrose saline on the reduction of post operation nausia and vomiting(PONV) after orthopedic surgery 2014-03-21 anticipated 310 Complete https://irct.ir/trial/21305 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A Postoperative Nausea and Vomiting. Intervention 1: In the control group: normal saline is used alone. All subjects received general anesthesia using midazolam( 0.1mg/kg ) propofol (2– 2.5 mg/kg)for induction and fentanyl 2µ/kg for analgesia and volatile anesthesia for maintenance.All patients were monitored by (blood pressure, pulse, oxygen saturation of arterial blood, electrocardiogram) . Intervention 2: In the intervention group: a combination of (5% dextrose and normal saline) were used. Infusion controlled by infusion pumps at 125 mL/h IV for 2 hours (250 mL) beginning with the start of surgical closure. This volume was chosen to provide small glucose supplements, and blood glucose increases after infusion.All subjects received general anesthesia using midazolam( 0.1mg/kg ) propofol (2– 2.5 mg/kg)for induction and fentanyl 2µ/kg for analgesia and volatile anesthesia for maintenance.All patients were monitored by (blood pressure, pulse, oxygen saturation of arterial blood, electrocardiogram) .
public Farzaneh Fazeli
Ghaem Hospital, Ahmad abad street, Mashhad
Mashhad Iran (Islamic Republic of) +98 51 3841 7402 fazelif911@mums.ac.ir Mashhad University of Medical Sciences scientific Reza Jallaiyan Taghadomi
Ghaem Hospital, Ahmad abad street, Mashhad
Mashhad Iran (Islamic Republic of) +98 51 3841 7402 fazelif911@mums.ac.irfhayati@ut.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria : • Age between 18 and 65 years undergoing orthopedic surgery • ASA class I and II exclusion criteria : • high blood pressure (severe) • liver or kidney disease •coagulopathy • Diabetes • Abnormal blood sugar on the morning of the day of surgery • severe hypotension during surgery that requires intravenous administration of large volumes • Lack of consent to participate in the study have 18 years 65 years Both T88.7 Unspecified adverse effect of drug or medicament Treatment - Drugs Treatment - Drugs In the control group: normal saline is used alone. All subjects received general anesthesia using midazolam( 0.1mg/kg ) propofol (2– 2.5 mg/kg)for induction and fentanyl 2µ/kg for analgesia and volatile anesthesia for maintenance.All patients were monitored by (blood pressure, pulse, oxygen saturation of arterial blood, electrocardiogram) . In the intervention group: a combination of (5% dextrose and normal saline) were used. Infusion controlled by infusion pumps at 125 mL/h IV for 2 hours (250 mL) beginning with the start of surgical closure. This volume was chosen to provide small glucose supplements, and blood glucose increases after infusion.All subjects received general anesthesia using midazolam( 0.1mg/kg ) propofol (2– 2.5 mg/kg)for induction and fentanyl 2µ/kg for analgesia and volatile anesthesia for maintenance.All patients were monitored by (blood pressure, pulse, oxygen saturation of arterial blood, electrocardiogram) . Severity of Postoperative Nausea and Vomiting. Timepoint: nausea and vomiting PNOV criteria at 30, 60, 120 minutes and 24 hours after ward admission. Method of measurement: It will be measured based on a verbal descriptive scalewhich is related with a visual analog nausea score. Recovery time. Timepoint: based on the time of patients' recovery time it will be different. Method of measurement: The time it takes after the surgery to the patient's recovery (in terms of minutes or hours). Vice Chancellor for research of Mashhad University of Medical Sciences Approved 2013-08-20 Ethics Committee of Mashhad University of Medical Sciences Mashhad University of Medical Sciences,Pardisan Mashhad Iran (Islamic Republic of)