IRCT2017102625488N2 IRCT 2017-11-04 Vice chancellor for research and technology, Arak University of Medical Sciences Effect of method of cardiac arresting on outcomes following bypass surgery Comparison of simultaneous antegrade.venous graft cardioplegia infusion to conventional method in coronary artery bypass grafting 2017-11-01 anticipated 178 Complete https://irct.ir/trial/21311 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Other design features: Simple randomization technique using SAS software version 9.4 will be applied for randomized allocation. N/A Condition 1: Coronary artery disease. Condition 2: Coronary artery bypass graft. Intervention 1: Intervention group: Mostly crystalloid cardioplegia (2% blood to prevent obscuring of the operative field), is infused continuously through vein grafts by a separate infusion set, once each distal anastomosis is completed at a rate of 10 to 20 mL per minute. This infusion is continued until half of the last distal anastomosis performed. The traditional method of intermittent cold blood (4 degrees Celsius) cardioplegia instillation, repeated every 20 minutes is implemented as well. Intervention 2: Control group: Antegrade cold blood cardioplegia (at a ratio of 4 to 1) is infused via aortic root by means of a cannula inserted by the surgeon at the middle part of ascending aorta. This injection conducting by the perfusionist, usually lasts about 3 minutes and should be repeated every 20 minutes (intermittent fashion).