IRCT2015122225660N1 IRCT 2016-02-28 Vice chancellor for research,Arak University of Medical Sciences analgesic effect of intravenous ketamine Comparison of analgesic effect of intravenous ketamine versus intravenous Morphine in isolated orthopedic trauma patients 2014-05-01 anticipated 606 Complete https://irct.ir/trial/21415 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Drugs were labeled by a study investigator as A or B in prefilled syringes in which both drug diluted until 0.1 milliliter of each syringe serve desired dose of the agent. We used 0.1 mg/kg dosage for morphine and 0.25 mg/kg for ketamine group. The eligible patients will be simply randomized in two treatment groups by using of randomized numbers table. The medication was administered by intravenous infusion during 5 minutes by registered treating nurse in a blinded fashion. 3 Condition 1: Upper or Lower limb fracture. Condition 2: Upper or Lower limb dislocation. Intervention 1: Intervention1 (case group): In Group A, patients receive a dose of 0.25 mg / kg iv ketamine. Drugs’ dose are calculated based on patient weight. Pain severity base on visual analog score (VAS) and complication such as dizziness, nausea, amnesia, headache, will be recorded at 0th, 5th, 10th and 20th minute. In patients with VAS of pain more than 50 mm at 20th minute, 0.05 mg/kg of intravenous morphine will be administrated as rescue analgesia . Intervention 2: Intervention2 (case group): In Group B, patients receive a dose of 0.1 mg / kg iv morphine. Drugs’ dose are calculated based on patient weight. Pain severity base on visual analog score (VAS) and complication such as dizziness, nausea, pain, amnesia, headache, will be recorded at 0, 5th, 10th and 20th minute. In patients with VAS of pain more than 50 mm at 20th minute, 0.05 mg / kg of intravenous morphine will be administrated as rescue analgesia.