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IRCT138806182438N1 IRCT 2010-03-01 Guilan University of Medical Sciences Comparison of usual versus high-dose rectal Acetaminophen in the treatment of febrile children Comparison of usual versus high-dose rectal Acetaminophen Comparison of usual versus high-dose rectal Acetaminophen in the treatment of febrile children refers to 17-Sharivar Hospital of Rasht- Iran, 2008-9. 1998-09-23 anticipated 80 Complete https://irct.ir/trial/2160 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Fever in children. Intervention 1: Acetaminophen, 30mg/kg , suppositiry, single dose at the initiation of fever. Intervention 2: Acetaminophen, 15mg/kg , suppositiry, single dose at the initiation of fever.
public Dr. Houman Hashemian, M.D.
17 Shahrivar Hospital- Namjoo st. - Rasht- Iran
Rasht Iran (Islamic Republic of) 4144654839 +98 13 1322 6101 hashemian@gums.ac.ir Guilan University of Medical Sciences- Medical Faculty- 17 Shahrivar Hospital of Rasht scientific Dr. Houman Hashemian, M.D.
17 Shahrivar Hospital- Namjoo st. - Rasht- Iran
Rasht Iran (Islamic Republic of) 4144654839 +98 13 1322 6101 hashemian@gums.ac.ir Medical Faculty, Guilan University of Medical Sciences- 17 Shahrivar Hospital of Rasht Iran (Islamic Republic of) Inclusion criteria: Age between 6 months and 6 years, rectal temperature 39- 40.5ºc, No presence of any of the following conditions: gastroenteritis in the 24 hours prior to the study, any medical or surgical condition that precluded rectal drug administration, acute or chronic hepatic disease, rectal bleeding, malabsorption syndromes, acute or chronic renal disease with the exception of urinary tract infection, chronic metabolic disease, chronic neurological disease that may affect central thermoregulation, Febrile convulsion in the previous 6 hours, cancer, immune suppression, sepsis, critical medical status, Antipyretic administration in the previous 8 hours, Antibiotic administration within 12 hours prior to the initiation of the study until 3 hours afterwards, or known allergy to Acetaminophen Exclusion criteria: Ejection of Acetaminophen suppository within 30 minutes after administration, Development of allergy to Acetaminophen no limit 6 years Both R50.9 Fever, unspecified Treatment - Drugs Treatment - Drugs Acetaminophen, 30mg/kg , suppositiry, single dose at the initiation of fever Acetaminophen, 15mg/kg , suppositiry, single dose at the initiation of fever Rectal Temperature. Timepoint: One and three hour after acetaminophen administration. Method of measurement: Rectal digital thermometer- Microlife. Guilan University of Medical Sciences Approved 2008-09-14 Medical Faculty (Vice-chancellor of research, Guilan University of Medical Sciences- Medical Faculty (Vice-chancellor of research)- Guilan University of Medical Sciences, Rasht, Guilan, Iran Rasht Iran (Islamic Republic of)