IRCT2016010825902N1 IRCT 2016-01-22 Vice chancellor For Research Of Ahvaz Jundishapur University of Medical Sciences The effect of dydrogesterone and various forms of progesterone in support of artificial reproduction techniques Comparison of oral dydrogesterone versus other forms of progesterone as a luteal cycles support in assisted reproductive technology (ART) 2015-10-18 anticipated 159 Complete https://irct.ir/trial/21608 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Initially, all patients are placed under transvaginal ultrasound then appropriate drugs is prescribed to patient for stimulation of ovulation based on patient cycle (short agonists and long agonist and antagonist). Transvaginal ultrasound is repeated once every five days. HCG will be prescribed when at least three follicles reach a diameter of over 18 mm. Ovum retrieval is done by transvaginal 36 hours after the injection HCG. In all patients will be prescribed dydrogesterone and progesterone for luteal phase support since ovum retrieval based on grouping patients. Embryo in the third to fifth day after ovum retrieval will be transferred to each patient with the number and grade of different. The criterion standard for pregnancy test is defined by a serum positive HCG on twelfth day after the fetal transfer and viewing the fetal heart on ultrasound. 2 Artificial fertilization. Intervention 1: Intervention group 1: Prescription oral dose of 10 mg of dydrogesterone, Three times a day, since ovum retrieval until the twelfth week of pregnancy. Intervention 2: Intervention group 2: Prescription 400 mg of progesterone vaginal suppository, twice a day, since ovum retrieval until the twelfth week of pregnancy. Intervention 3: Control group: Prescription 50 mg of intramuscular progesterone, twice a day, since ovum retrieval until the twelfth week of pregnancy.