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IRCT2016011225982N1 IRCT 2016-01-25 Ahvaz Jundishapur University of Medical Sciences Comparison between clonidine and Dexmedetomidine as premedication on hemodynamic changes and intraoperative bleeding Comparison between clonidine and Dexmedetomidine as premedication on hemodynamic changes and intraoperative bleeding in spine surgery 2015-05-22 anticipated 120 Complete https://irct.ir/trial/21661 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. N/A Condition 1: Bleeding. Condition 2: Hemodynamic Changes. Intervention 1: The first group intervention: clonidine 0.2 mg tablets 45 minutes before induction of anesthesia and saline infusion as a placebo to 100 ml 15 minutes before induction of anesthesia. Intervention 2: The second group intervention: placebo tablets and infusion Dexmedetomidine 0.5 micrograms per kg in 100 mL normal saline 15 minutes before induction of anesthesia to continue the infusion of 0.25 mg per kg per hour, pump the syringe 20 mL with a concentration of 5 mg/ cc. Intervention 3: Control group: placebo tablets with 100 mL of normal saline infusion took 15 minutes before induction of anesthesia.
public Mahshid Vaziri
Golestan Blvd., Ahvaz Golestan hospita-Generall operating room
Ahvaz Iran (Islamic Republic of) +98 61 3221 6504 vaziri.m@ajums.ac.ir Ahvaz Jundishapur University of Medical Sciences scientific Farahzad Janatmakan
Golestan Blvd., Ahvaz Golestan hospital-General operating room
Ahvaz Iran (Islamic Republic of) 00 Fjanatmakan@yahoo.com Ahvaz Jundishapur University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria were as follows: age range of 20 to 50 years, ASA class 1 or 2 and spine surgery candidates. Exclusion criteria included patients with hypertension, diabetes, clotting problems, ischemic heart disease, drug or alcohol abuse, pregnancy, taking beta blockers or calcium channels blockers drugs and operating time of over 120 minutes. 20 years 50 years Both T81 R00.0, R00 Complications of procedures, not elsewhere classified Tachycardia (unspecified), Bradycardia (unspecified), Palpitations Treatment - Other Treatment - Other Placebo The first group intervention: clonidine 0.2 mg tablets 45 minutes before induction of anesthesia and saline infusion as a placebo to 100 ml 15 minutes before induction of anesthesia The second group intervention: placebo tablets and infusion Dexmedetomidine 0.5 micrograms per kg in 100 mL normal saline 15 minutes before induction of anesthesia to continue the infusion of 0.25 mg per kg per hour, pump the syringe 20 mL with a concentration of 5 mg/ cc Control group: placebo tablets with 100 mL of normal saline infusion took 15 minutes before induction of anesthesia Intraoperative bleeding. Timepoint: Ending surgery. Method of measurement: Including suction bottle and blood gauzes. Heart Rate. Timepoint: One minute after intubation, 10, 20, 30 minutes after induction of anesthesia and after extubation. Method of measurement: ECG Monitoring. Blood Pressure. Timepoint: One minute after intubation, 10, 20, 30 minutes after induction of anesthesia and after extubation. Method of measurement: Invasive blood pressure monitoring. Mean Arterial Pressure. Timepoint: One minute after intubation, 10, 20, 30 minutes after induction of anesthesia and after extubation. Method of measurement: Invasive blood pressure monitoring. Ahvaz Jundishapur University of Medical Sciences Approved 2015-11-21 Ahvaz Jundishapur University of Medical Sciences Golestan Blvd., Ahvaz, Khuzestan Ahvaz University of Medical Sciences Ethics Committee Ahvaz Iran (Islamic Republic of)