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IRCT2016011626038N1 IRCT 2016-05-08 Nuclear Medicine Research Center comparing treatment efficacy of high versus low dose iodine ablation in intermediate risk thyroid cancer patients referring to thyroid clinic of nuclear medicine department of GHAEM hospital in the years 1392 to 1395 LOH(low or high) Treatment efficacy of high versus low dose post thyroidectomy iodine ablation in intermediate risk patients with differentiated thyroid cancer , refering to thyroid clinic of nuclear medicine department of GHAEM hospital in the years 1392 to 1395. 2014-12-31 anticipated 150 Complete https://irct.ir/trial/21688 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2 Malignant neoplasm of thyroid gland. Intervention 1: administration of 150 mci of I131. Intervention 2: administration of 30mci of I131.
public Dr.Athena Aghaee
Ghaem Hospital-Ahmad Abad Avenue
Mashhad Iran (Islamic Republic of) +98 51 3840 9611 aghaeea911@mums.ac.ir Mashhad University of Medical Sciences scientific Dr.Seyed Rasool Zakavi
Ghaem Hospital; Ahmad Abad Avenue
Mashhad Iran (Islamic Republic of) +98 915 110 7844 zakavir@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Inclusion:age more than 18 years/ diagnosis of DTC by a reliable pathology/history of total thyroidectomy / recieved no other treatments such as radiotherapy and/or iodine ablation after surgery/ no evidence of distant metastasis at initial evaluation/ categorizing in either of these groups: age more than 45 yeras: T1N1b,T2N0,T2N1a,T3N0; age less than 45 years: T21a,T2N1b,T3N0,T3N1a Exclusion: incomplete thyroid surgery; first serum Throglobulin level more than 60 ng/dl; distant metastasis/ T4 18 years 100 years Both (C73) Malignant neoplasm of thyroid gland Treatment - Drugs Treatment - Drugs administration of 150 mci of I131 administration of 30mci of I131. Response to treatment categorize as 3 groups: excellent response, acceptable response and incomplete response. Timepoint: 1 year after treament. Method of measurement: according to patients lab test in the off drug status, such as thyroglobulin, anti thyroglobulin , neck ultrasonography and diagostic whole body iodine scan,if needed. Serum thyroglobulin. Timepoint: 1 year after treatment. Method of measurement: lab data. Nuclear Medicine Research Center Approved 2013-10-05 Mashhad University of Medical Sciences Mashhad University of Medical Sciences, Park square, Mashhad mashhad Iran (Islamic Republic of)