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IRCT2016020626394N1 IRCT 2016-08-23 Vice chancellor for research, Arak University of Medical Sciences Study of Effect of Myrtus extract on diabetic foot wounds Clinical trial to evaluate the effect of Myrtus extract on healing of diabetic foot wounds 2016-02-20 anticipated 70 Complete https://irct.ir/trial/21890 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Restricted randomization. 2-3 Diabetic Foot Ulcers. Intervention 1: Intervention group: standard treatment for diabetic foot ulcers will accomplish based on infection control, pressure and if necessary debridement of necrotic tissue. Oral antibiotic therapy appropriate to the condition of patient will admit and wound cleaning with normal saline will perform. In addition herbal extracts will use as wound washing with normal saline, spray of the extract with insulin syringe on the wound, gauze embedded with the extract will put on the wound and will be tied. This will perform 2 to 4 times depending on the patient's condition. Treatment by extract will be increased in cases with more severe lesions or toes will float in the extract for about 15 minutes if necessary, according to depth of the wound. Intervention 2: Control group: Standard treatment for diabetic foot ulcers will accomplish based on infection control, pressure removal and if necessary debridement of necrotic tissue. Oral antibiotic therapy appropriate to the condition of patient will admit and wound cleaning with normal saline will perform.
public Ghasem Habibi Dehfooli
Pardis of Arak University of Medical Sciences, Sardasht, Basidj Bidge, Arak, IR. IRAN
Arak Iran (Islamic Republic of) +98 86 3417 3505 ghasemhabibi.chem@gmail.com Infectious Diseases Research Center scientific Dr. Mohammad Arjomandzadegan
Pardis of Arak University of Medical Sciences, Sardasht, Basidj Bidge, Arak, IR. IRAN
Arak Iran (Islamic Republic of) +98 86 3417 3505 mmatinam81@yahoo.com Infectious Diseases Research Center, Arak University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Proved diabetes; clinical findings indicative for wound infection (redness, swelling and discharge; diabetic foot wound), wounds on toes; foot, the heel and top of the toe; body mass index 18 to 35; full consciousness, age 20 to 80 years. The exclusion criteria: drugs and alcohol abuse; chronic disease other than diabetes affects the healing process of wounds such as severe vascular disease, lupus, rheumatoid arthritis, burgers and kidney failure; Immunosuppressive and cytotoxic drug users. 20 years 80 years Both E10 diabetes, With peripheral circulatory complications Treatment - Drugs Treatment - Drugs Intervention group: standard treatment for diabetic foot ulcers will accomplish based on infection control, pressure and if necessary debridement of necrotic tissue. Oral antibiotic therapy appropriate to the condition of patient will admit and wound cleaning with normal saline will perform. In addition herbal extracts will use as wound washing with normal saline, spray of the extract with insulin syringe on the wound, gauze embedded with the extract will put on the wound and will be tied. This will perform 2 to 4 times depending on the patient's condition. Treatment by extract will be increased in cases with more severe lesions or toes will float in the extract for about 15 minutes if necessary, according to depth of the wound. Control group: Standard treatment for diabetic foot ulcers will accomplish based on infection control, pressure removal and if necessary debridement of necrotic tissue. Oral antibiotic therapy appropriate to the condition of patient will admit and wound cleaning with normal saline will perform. Grade of diabetic foot ulcers. Timepoint: Before the intervention and every weeks up to four weeks after the intervention. Method of measurement: Grade and depth of diabetic foot ulcers in both control and experimental groups before the intervention, according to the University of Texas wound classification system will be assessed by the investigator. Vice chancellor for research, Arak University of Medical Sciences Approved 2016-01-26 Ethics committee of Arak University of Medical Sciences Pardis of Arak University of Medical Sciences, Basidj Bridge, Sadasht, Arak, IR. IRAN Arak Iran (Islamic Republic of)