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IRCT2016020726411N1 IRCT 2016-03-14 Ministry of Research and Technology Iran University of Medical Science assesment of immunmodulatory effect of β Glucan on wound healing in burn patients assesment of immunmodulatory effect of β Glucan on wound healing ,A two parallel group randomized clinical trial 2016-04-08 anticipated 124 Complete https://irct.ir/trial/21903 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: According Block Randomization and regarding 4 blocks,31 block will produce for 124 patients. 3 Condition 1: Burn wound. Condition 2: Burn wound. Intervention 1: The patients divide two groups: The first one is control group that receive the usual wound care protocol (silver sulfadiazine). Intervention 2: The second group comprising patients that receive extracted beta Glucan in local form plus silver ointment.
public Dr Maryam Roudbary
school of Medicine,Department of Mycology and parasitology
Tehran Iran (Islamic Republic of) +98 21 8670 3296 m_roudbary@yahoo.comroudbari.mr@iums.ac.ir Iran university of Medical science scientific Maryam Roudbary
Hemmat west Highway,Intervention shikh Fazlollah and Chamran,Iran University Of Medical Science
Tehran Iran (Islamic Republic of) +98 21 8670 1108 m_roudbary@yahoo.com School of Medicine,Iran university of medical science,Tehran,iran Iran (Islamic Republic of) According the similar studies in wound healing by using other imperious agents and attitude skin healing physician in motahari hospital, in this study inclusion criteria are;the age of patients:18-50 years.burn classification: second level and <50% of body surface is burned.Gender;two gender(male , famale) Exclusion criteria: the women with pregnancy; the patients with immunodeficiency, immunosuppression drug consumption; acute infections ;Liver and Kidney diseases .The pateints don’t permit to enter the other clinical trial during this study. 18 years 50 years Both Treatment - Drugs Treatment - Drugs The patients divide two groups: The first one is control group that receive the usual wound care protocol (silver sulfadiazine) The second group comprising patients that receive extracted beta Glucan in local form plus silver ointment Decrease at least 25% wound surface. Timepoint: decreasing the wound size in first week of care,the third day and end of second week and finally end of treatment. Method of measurement: centimeter. TNF Alpha. Timepoint: End of study(8th week). Method of measurement: ELISA and OD. IFN gamma. Timepoint: End of study(8th week). Method of measurement: ELISA and OD. IL1. Timepoint: End of study(8th week). Method of measurement: ELISA and OD. Ministry of Research and Technology Iran University of Medical Science Approved 2015-10-07 Ethics committee of Iran University of Medical Sciences Hemat west highway,intervention shikh fazollah nori and chamran Tehran Iran (Islamic Republic of)