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IRCT138807052474N2 IRCT 2010-01-09 Research vice-chancellor of Tabriz University of Medical Sciences The Effect of prethrombolytic Cyclosporine A injection on Acute Anterior ST-Elevation Myocardial Infarction Outcome. The Effect of prethrombolytic Cyclosporine A injection on Acute Anterior ST-Elevation Myocardial Infarction Outcome. 2009-06-22 anticipated 100 Complete https://irct.ir/trial/2203 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Acute myocardial infarction. Intervention 1: Cyclosporine 2.5 mg/kg in intervention group (pre thrombolytic). Intervention 2: Normal saline in control group (pre thrombolytic).
public Dr Mehdi Toluey Khormazard
Shahid Madani Heart Center, Daneshgah Ave.
Tabriz Iran (Islamic Republic of) +98 914 301 8779 drmtoluey@yahoo.com Tabriz University of Medical Sciences scientific Dr Samad Ghaffari
Shahid Madani Heart Center
Tabriz Iran (Islamic Republic of) +98 914 313 7973 ghafaris@gmail.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria : in patients with 18 years of age or older, presence of ischemic chest pain and ST segment elevation of 1 mm or more in at least two contiguous leads of anterior region, who admits in primary six hours of symptoms onset and candidate for thrombolytic therapy Exclusion criteria : cardiac arrest, primary VF, prior MI, uncontrolled HTN, known hypersensitivity to cyclosporine, known renal failure or a serum creatinine level of 120 mol per liter (1.36 mg per deciliter) or more at admission, liver failure, and women who were pregnant or who were of childbearing age and were not using contraception, any disorder that is associated with immunologic dysfunction e.g., cancer, lymphoma, a positive serologic test for the human immunodeficiency virus, or hepatitis 20 years 85 years Both I21.0 Acute transmural myocardial infarction of anterior wall Treatment - Drugs Treatment - Drugs Cyclosporine 2.5 mg/kg in intervention group (pre thrombolytic) Normal saline in control group (pre thrombolytic) LVEF. Timepoint: 1st day & predischarge. Method of measurement: echocardiography. Incidence of Heart Failure. Timepoint: During admission. Method of measurement: Basal pulmonary rales , lasix using, chest XRAY. Incidence of Arrhythmia. Timepoint: During admission. Method of measurement: ECG monitoring. All cause mortality rate. Timepoint: in hospital & 6 month later. Method of measurement: patient documents & calling. Research vice-chancellor of Tabriz University of Medical Sciences Approved 1387-12-05 Tabriz University of Medical Sciences Tabriz University of Medical Sciences, Daneshgah Ave. Tabriz Iran (Islamic Republic of)