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IRCT2016030226872N1 IRCT 2016-06-29 Ethics committee of Kermanshah University of Medical Sciences Effect of Tetracycline in the treatment of chronic periodontitis Comparative Evaluation of Mucoadhesive Locally Delivery Tetracycline Gel and Tetracycline Gel in Treatment of Chronic Periodontitis 2016-05-21 anticipated 75 Complete https://irct.ir/trial/22165 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Patients are recruited from people refer to periodontics department of Kermanshah University Of Medical Science. Each patient will receive different treatment modalities in each quadrant. Randomization was done by toss of coin for quadrants and treatment modalities. 2 Chronic periodontitis. Intervention 1: Control group:SRP with placebo. Intervention 2: Intervention group:SRP with Mucoadhesive Locally Delivery Tetracycline 5%. Intervention 3: Intervention group:SRP with Tetracyclin 5%.
public Marzie Jamali
Opposite of the post office, Shora st, Dr Shariati st, Kermanshah
kermanshah Iran (Islamic Republic of) +98 83 3722 2400 m.jamali174@gmail.com Kermanshah Dentistry School scientific Dr Maryam Khosravi
Opposite of the post office, Shora st, Dr Shariati st, Kermanshah
Kermanshah Iran (Islamic Republic of) +98 83 3722 2400 m.khosravi@kums.ac.ir Kermanshah Dentistry School Iran (Islamic Republic of) Inclusion criteria: patient free from systemic illness; patients who had note history of allergy to tetracycline; patiens having at least three sites with minimum 5 mm periodontal pocket; patient who had not taken antibiotic therapy and prophylaxy and periodontal therapy in the past 6 month Exlusion criteria: dissatisfaction and inability to comply with the follow-up visit requirments; history of systemic illness; received antibiotic treatment 2 weeks prior to study; pregnant and nursing patients 30 years 60 years Both K05.3 Chronic periodontitis Placebo Treatment - Drugs Treatment - Drugs Control group:SRP with placebo Intervention group:SRP with Mucoadhesive Locally Delivery Tetracycline 5% Intervention group:SRP with Tetracyclin 5% Probing pocket depth. Timepoint: Baseline, two weeks, one and three months after the intervention. Method of measurement: Williams Periodontal Probe. Clinical attachment loss. Timepoint: Baseline, two weeks, one and three months after the intervention. Method of measurement: Williams Periodontal Probe. Plaque index. Timepoint: Baseline, two weeks, one and three months after the intervention. Method of measurement: plaque index Silness & Loe. Gingival Index. Timepoint: Baseline, two weeks, one and three months after the intervention. Method of measurement: Observed. Bleeding Index. Timepoint: Baseline, two weeks, one and three months after the intervention. Method of measurement: Observed\Bleeding Index Muhlemann. Ethics committee of Kermanshah University of Medical Sciences Approved 2016-01-20 Kermanshah University of Medical Sciences Kermanshah University of Medical Sciences, Shahid Beheshti blvd, Kermanshah Kermanshah Iran (Islamic Republic of)