IRCT2016031427045N1 IRCT 2016-05-09 Vice Chancellor for Research, Tehran University of Medical Sciences The effect of low dose hCG with GnRH agonist in decreasing rate of ovarian hyper stimulation syndrome in IVF cycles. The effect of low dose hCG with GnRH agonist in decreasing rate of ovarian hyper stimulation syndrome in IVF cycles in Omid clinic and Shariati hospital in Teharn in 1394 and 1395. 2015-12-28 anticipated 80 Complete https://irct.ir/trial/22265 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 3 Female infertility. Intervention 1: Interventional group receives 150 IU FSH daily from the second day of menses. When the 14 mm follicles is observed in transvaginal ultrasound GnRH antagonist (Cetrorelix) 0.25mg subcutaneously daily is added. After the observation of at least two 18mm follicles, GnRH agonist (Bucerellin 0.5 mg) is injected. After 36 hours, low dose hCG is injected and oocyte retrieve is performed under general anesthesia. Three days after fertilization, transcervical embryo transfer will be carried out. Symptoms and signs of OHSS (Abdominal pain, Oliguria, Weight gaining, Nausea and Vomiting) are evaluated during 2 weeks after oocyte retrieval. Pregnancy test is checked 14 days after embryonal transfer. 2 weeks after positive test, by the aid of transvaginal ultrasound the pregnancy sac and fetal heart are detected. Intervention 2: Control group, receives 150 IU FSH daily from the second day of menses. When the 14 mm follicles is observed in transvaginal ultrasound GnRH antagonist (Cetrorelix) 0.25mg subcutaneously daily is added. After the observation of at least two 18mm follicles, GnRH agonist (Bucerellin 0.5 mg) and low dose hCG are injected. After 36 hours oocyte retrieve is performed under general anesthesia. Three days after fertilization, transcervical embryo transfer will be carried out. Symptoms and signs of OHSS (Abdominal pain, Oliguria, Weight gaining, Nausea and Vomiting) are evaluated during 2 weeks after oocyte retrieval. Pregnancy test is checked 14 days after embryonal transfer. 2 weeks after positive test, by the aid of transvaginal ultrasound the pregnancy sac and fetal heart are detected.