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IRCT201110312499N2 IRCT 2011-12-02 Vice Chancellor For Research, Mazandaran University of Medical Sciences comparison of sequential-concomitant hybrid to sequential therapy in h.pylori eradication rate sequential-concomitant (hybrid) hybrid therapy in H.pylori 2011-03-21 anticipated 296 Complete https://irct.ir/trial/2231 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A PUD(H.PYLORI ERADICATION REGIMEN). Intervention 1: Intervention group: pantoprazole 40mg (BD) + Amoxicillin 1g (BD) + Clarithromycin 500mg (BD) and Tinidazole 500mg (BD) during the first 2 weeks. Intervention 2: Control group: pantoprazole 40mg (BD) for 10 days + Amoxicillin 1g (BD) just during the first 5 days + Clarithromycin 500mg (BD) and Tinidazole 500mg (BD) just during the second 5 days.
public Dr Hafez Tirgar Fakheri
Imam Khomeini Hospital, Razi street,Internal Medicine Department, Sari Mazandaran Iran, Islamic Republic Of 00981512261700 00989111521404 00981512264044
Sari Iran (Islamic Republic of) 00981512261700 00989111521404 00981512264044 Hfakheri@mazums.ac.ir fakheri42@yahoo.com Mazandaran University of Medical Sciences scientific Dr. Hafez Tirgar Fakheri
Imam Khomeini Hospital, Razi street, Internal Medicine Department, Sari ,Mazandaran
Sari Iran (Islamic Republic of) 00981512261700 00989111521404 00981512264044 Hfakheri@mazums.ac.ir fakher42@yahoo.com Mazandaran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: age more than 18 years and less than 80 years with duodenal or gastric ulcers; duodenal or gastric erosions and helicobacter pylori positivity. Exclusion criteria: Previous history of receiving any H.pylori eradication regimen, Taking H2 blocker, proton pump inhibitor, Bismuth or Antibiotics during the 2 weeks prior to the study, Taking anticoagulants, ketoconazole or corticosteroids, History of gastric or esophageal surgery, Severe cardiovascular, pulmonary or endocrine disease, Renal failure, Hepatic diseases, Malignancies, Alcoholism, Pregnancy or breast feeding 18 years 80 years Both K25.9,K26. GASTRIC ULCER,DUODENAL ULCER,PEPTIC ULCER DISEASE, GASRTRODUODENITIS Treatment - Drugs Treatment - Drugs Intervention group: pantoprazole 40mg (BD) + Amoxicillin 1g (BD) + Clarithromycin 500mg (BD) and Tinidazole 500mg (BD) during the first 2 weeks Control group: pantoprazole 40mg (BD) for 10 days + Amoxicillin 1g (BD) just during the first 5 days + Clarithromycin 500mg (BD) and Tinidazole 500mg (BD) just during the second 5 days Helicobacter pylori eradication rate. Timepoint: 2 months after the completion of treatment course. Method of measurement: urease breath test. Side effects of drugs. Timepoint: daily recording during and after the treatment course. Method of measurement: classifying as mild, moderate or severe side effects. Vice Chancellor For Research, Mazandaran University of Medical Sciences Approved 2011-08-07 Mazandaran University of Medical Sciences Imam Khomeini Hospital, Sari, Razi street Sari Mazandaran sari Iran (Islamic Republic of)