IRCT2016050527643N2 IRCT 2016-05-23 Vice Chancellor for Research of Sabzevar University of Medical Sciences cervical ripening and termination of term pregnancy The Effects of vaginal Misoprostol, Laminaria and Isosorbide Dinitrate on cervical ripening before labor induction among the term parturients 2016-05-17 anticipated 96 Complete https://irct.ir/trial/22604 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A vaginal delivery. Intervention 1: in the first group, Misoprostol, 25 microgram of this drug as oral Tablet will insert in posterior fornix of vagina.The dose can be repeated up to 2 times every 6 hours. The second doses, if Bishop score is less than 8 per examination will be repeated every 6 hours. Administration of low dose Oxytocin immediately after preparation of the cervix (active phase of labor with utrine contracture less than 3 in 10 minutes ) or no response to procedures will be performed after 12 hours. Intervention 2: in the second group, Isosorbide Dinitrate, 40 milligram of this drug as Oral Tablets will insert to the mother's vagina in Posterior Fornix. The dose can be repeated up to 3 times every 4 hours. The second and third doses, if Bishop is less than 8 will be repeated every 4 hours. Administration of low dose Oxytocin immediately after preparation of the cervix (active phase of labor with utrine contracture less than 3 in 10 minutes ) or no response to procedures will be performed after 12 hours. Intervention 3: In third group, first, maternal vagina will be cleaned with Bethadine. After the Speculum inserted, the anterior lip of the Cervix will be taken with Tenaculum and Laminaria will be taken down depending on the size of the cervix so that its tip has been diced near the internal opening of the cervix.Then after 12 hours Laminara will be taken out. Administration of low dose Oxytocin immediately after preparation of the cervix (active phase of labor with utrine contracture less than 3 in 10 minutes ) or no response to procedures will be performed after 12 hours.