]>
IRCT2016042827652N1 IRCT 2016-05-04 Vice Chancellor for research of Ahvaz Jundishapur University of Medical Sciences Effect of ginger powder supplement on nonalcoholic fatty liver disease The effect of ginger powder supplement on lipid profile, insulin resistance, antioxidant status, inflammatory biomarkers and fatty liver index in owerweight and obese patients with Nonalcoholic fatty liver disease(NAFLD). 2016-04-29 anticipated 46 Complete https://irct.ir/trial/22609 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 3 Nonalcoholic Fatty Liver Disease. Intervention 1: intervention group:Three ginger capsules 500 mg daily for 12 week. Intervention 2: The placebo group:Three placebo daily for 12 weeks.
public Roya rafie
Golestan Ave., Paramedical School, Department of Nutrition, Ahvaz Jundishapur University of Medical Sciences
Ahvaz Iran (Islamic Republic of) +98 61 3333 3050 rafie.r@ajums.ac.ir Ahvaz Jundishapur University of Medical Sciences scientific Seyyed ahmad hosseini
Golestan Ave., Paramedical School, Department of Nutrition, Ahvaz Jundishapur University of Medical Sciences
Ahvaz Iran (Islamic Republic of) +98 61 3333 3050 seyedahmadhosseini@yahoo.com Ahvaz Jundishapur University Of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Men or women aged between 20 to 70 years old who will be diagnosed with NAFLD by ultrasonography scan (with steatosis score equal or greater than 1) and increased levels of liver enzymes (serum levels of alanine aminotransferase and aspartate aminotransferase more than 40 U/L); and Body Mass Index (BMI) of them is greater than 24.9 and lower than 35. Exclusion criteria: Alcohol consumption; Pregnant and lactating women; Any known forms of hepatic or metabolic disease except NAFLD, such as hereditary hemochromatosis, Wilson’s disease, cirosis, diabetes and other metabolic disease; Any history of gastric bypass or intestine surgery; Taking hepatotoxic drugs such as calcium channel blocker, methotrexate, amiodarone, chloroquine and anti inflammatory drugs; Using nutrition supplements; Hormone Therapy; and Patients with a history of hypothyroidism, Cushing’s syndrome, renal failure, and kidney stones. 20 years 70 years Both K76.0 Fatty (change of) liver, not elsewhere classified Treatment - Drugs Placebo intervention group:Three ginger capsules 500 mg daily for 12 week The placebo group:Three placebo daily for 12 weeks Liver steatosis index. Timepoint: Before and after intervention. Method of measurement: Sonography. Insulin Resistance (IR). Timepoint: Before and after intervention. Method of measurement: Based on HOMA IR equation. Liver enzymes (ALT, AST, ALP, GGTٰٰٰ). Timepoint: Before and after intervention. Method of measurement: Microgram/ml - laboratory kit. Tomor necrosis factor alpha (TNF alpha). Timepoint: Before and after intervention. Method of measurement: ELISA. Serum Total Anti Oxidant Capacity (TAOC). Timepoint: Before and after intervention. Method of measurement: ELISA. High sensitive C reactive protein. Timepoint: Before and after intervention. Method of measurement: ELISA. Fetuin A. Timepoint: Before and after intervention. Method of measurement: ELISA. Lipid profile (TG, LDL, HDL, Total cholestrol). Timepoint: Before and after intervention. Method of measurement: laboratory kit. Insulin. Timepoint: Before and after intervention. Method of measurement: ELISA. Fasting Blood Sugar (FBS). Timepoint: Before and after intervention. Method of measurement: Colorimetric enzymatic method. Waist to hip ratio. Timepoint: Before and after intervention. Method of measurement: Non-stretchable tape without any pressure. Body Mass Index (BMI). Timepoint: Before and after intervention. Method of measurement: Weight (kilograms) divided by the square of height (meters). Sistolic and diastolic blood pressure. Timepoint: Before and after intervention. Method of measurement: By mercury sphygmomanometer. Fatty liver index. Timepoint: Before and after intervention. Method of measurement: Based on the equation. Vice Chancellor for research of Ahvaz Jundishapur University of Medical Sciences Approved 2016-04-16 The Ethics Committee of Ahvaz Jundishapur University of Medical Science The Ethics Committee, Vice Chancellor for Research and Technology, Ahvaz Jundishapur University of Medical Sciences, University City, Golestan blvd. Ahvaz Iran (Islamic Republic of)