IRCT2016050727729N2 IRCT 2016-05-28 Vice Chancellor for Research and Technology of Shahid Sadoughi University of Medical Sciences Comparison of the effects of flaxseed and sesame powder on the antioxidant activity and blood profile of patients with mild to moderate hypertension Comparison of the effects of flaxseed and sesame powder on the antioxidant activity and blood profile of patients with stage I hypertension 2016-05-28 anticipated 90 Complete https://irct.ir/trial/22655 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Hypertension. Intervention 1: Group A receives 30 grams of powdered flaxseed by eating 90 gram bread daily for 14 weeks. Intervention 2: Group B receives 30 grams of of powdered sesame by eating 90 gram bread daily for 14 weeks.

public Moneyreh Modares Mosadegh

Alem square

Alem Square

Yazd Iran (Islamic Republic of) 8915173149 +98 35 3820 3419 modares@ssu.ac.ir; mo_modares@yahoo.com; moneyrehmodares@gmail.com Shahid Sadoughi University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: age between 30 to 65 years; stage I hypertension (Systolic Blood Pressure (SBP) 140-159 mmHg, Diastolic Blood Pressure (DBP) 90-99 mmHg); using a particular anti-hypertensive therapy for at least 3 months; cholesterol less than 240 mg/dl. Exclusion Criteria: pregnant women or women planning to get pregnant; being allergic to sesame or flaxseed; suffering from intestinal diseases such as Crohn's disease, colitis, peptic ulcer, irritable bowel syndrome (IBS), and other severe systemic diseases such as systemic lupus erythematosus (SLE), cancer, or stage IV respiratory diseases; history of myocardial infarction; coronary bypass surgery during last 6 months; stage II hypertension; diabetes; routinely using nonsteroidal anti-inflammatory drugs (NSAID's); change of anti-hypertensive drugs during the study; using drugs for hyperlipidemia 30 years 65 years Both I10 Essential (primary) hypertension Treatment - Other Treatment - Other Group A receives 30 grams of powdered flaxseed by eating 90 gram bread daily for 14 weeks Group B receives 30 grams of of powdered sesame by eating 90 gram bread daily for 14 weeks Free radical scavenging capacity. Timepoint: prior to study, Seventh week, and at the end of study. Method of measurement: this is showed in % and is obtained by measuring DPPH (1,1-diphenyl-2-picryl hydrazyl radical). This measurement is done by Elisa. Malondialdehyde (MDA). Timepoint: prior to study, Seventh week, and at the end of study. Method of measurement: micromol/L; it is measured by Elisa. Cholesterol. Timepoint: prior to study, Seventh week, and at the end of study. Method of measurement: mg/dL. Triglyceride. Timepoint: prior to study, Seventh week, and at the end of study. Method of measurement: mg/dL. Low density lipoprotein (LDL). Timepoint: prior to study, Seventh week, and at the end of study. Method of measurement: mg/dL. High density lipoprotein (HDL). Timepoint: prior to study, Seventh week, and at the end of study. Method of measurement: mg/dL. Vice Chancellor for Research and Technology of Shahid Sadoughi University of Medical Sciences Approved 2016-03-02 Shahid Sadoughi University of Medical sciences Alem square Yazd Iran (Islamic Republic of)