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IRCT138807112539N1 IRCT 2009-11-08 Arak University of Medical Sciences Assessment of Colchicine efficacy in treatment of chronic hepatitis B A comparative evaluation of combination therapy of Lamivudine and Colchicine comparing with Lamivudine and placebo in clinical and laboratory improvement of chronic hepatitis B 2009-07-06 anticipated 100 Complete https://irct.ir/trial/2279 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomized, double-blind,parallel, controlled trial. 3 Chronic viral hepatitis B. Intervention 1: Lamivudine, 100 mg daily and Colchicine 0.5mg daily for 6 months. Intervention 2: Lamivudine 100 mg daily and placebo once daily for 6 months.
public Dr Amir Hassanpour
Amiralmomenin Hospital
Arak Iran (Islamic Republic of) 3848176941 +98 86 1417 3608 drhassanpor@arakmu.ac.ir Arak University of Medical Sciences scientific Dr Ali Fani
Amiralmomenin Hospital
Arak Iran (Islamic Republic of) 3848176941 +98 86 1417 3608 biva23fani@arakmu.ac.ir Arak University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: positive HBS Ag, confirmed chronic hepatitis B, ALT level at least twofold of normal range Exclusion criteria: positive HCV Ab, positive HIV Ab, Alcohol abuse, Presence of auto immune hepatitis, metabolic liver disease, right cardiac failure or pulmonary hypertension, low compliance, allergic reaction to drugs or sever side effect of drugs, presence of decompensate cirrhosis (PT>20 sec and ALb<3 gr/dl) 15 years 70 years Both B 18.1 Chronic viral hepatitis B Treatment - Drugs Treatment - Drugs Lamivudine, 100 mg daily and Colchicine 0.5mg daily for 6 months Lamivudine 100 mg daily and placebo once daily for 6 months Treatment of chronic hepatitis B. Timepoint: One month before intervention and one month after intervention. Method of measurement: Laboratory measurement of serum ALT- Albumin-bilirubin and PT. Arak University of Medical Sciences Approved Ethics committee of Arak University of Medical Sciences Shahid Shiroodi Avenue,Allamolhoda Str Arak Iran (Islamic Republic of)