IRCT2016052127982N1 IRCT 2016-07-02 Vice chancellor for research,Gonabad University of Medical Sciences Comparison of the effect of Hugo point pressure massage with and without ice on pain due to vaccination Comparison of the effect of Hugo point pressure massage with and without ice on pain due to Pentavalent vaccine in infants 2016-05-29 anticipated 72 Complete https://irct.ir/trial/22799 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Other design features: Sampling method: it will be done through convenience sampling and random allocation using permutation blocking method. Blinding: intervention and control groups include two-month infants who are naturally blind in terms of the intervention target.( MBPS tool is used to measure pain scale based on three criteria of face change, crying and body movements of infants.) Pain scale is measured by someone not aware of the type of intervention. Data are also analyzed by someone not aware of the intervention and control groups. 2-3 Factors influencing health status and contact with health services. Intervention 1: Hugo point of the right hand will be massaged for 1 minute using ice cube covered in plastic glove and one-layer cotton cloth for second test group; the intervention is repeated twice after 30s relaxation. Intervention 2: Infants of the control group will be put on the bed without any intervention and based on the usual procedure of the center. Intervention 3: Hugo point of the right hand will be massaged for 1 minute using soft part of the thumb in first test group and the intervention will be repeated twice after 30s relaxation.