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IRCT2016061228407N1 IRCT 2016-06-25 Zahedan University of Medical Sciences The effectiveness of CoQ10 antioxidant supplements in the prevention of the harmful effects of occupational exposure to heavy metals and organic solvents The study of the protective effect efficiency of antioxidant CoQ10 supplement on blood levels of total antioxidant capacity, antioxidant enzymes activity and malondialdehyde of workers in ceramic and printing industries 2016-07-10 anticipated 80 Complete https://irct.ir/trial/23057 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Prevention. N/A Condition 1: Toxic effect of organic solvents. Condition 2: Toxic effect of metals. Condition 3: Toxic effect of metals. Intervention 1: The intervention group consists of 20 workers exposed to organic solvents in the printing industry and 20 workers exposed to heavy metals in the tile industry who received capsules 60 mg oral COQ10 twice daily for 60 days. Intervention 2: The control group consists of 20 workers exposed to organic solvents in the printing industry and 20 workers exposed to heavy metals in the tile industry who received capsules 60 mg oral placebo twice daily for 60 days.
public Maryam Hormozi
Doctor Hesabi Square
Zahedan Iran (Islamic Republic of) 9816743175 +98 54 3348 8718 hormozym@yahoo.comdr.hormozi@zaums.ac.ir Zahedan University of Medical Sciences scientific Ramazan Mirzaei
Doctor Hesabi Square
Zahedan Iran (Islamic Republic of) +98 54 3329 5827 mirzaei@zaums.ac.ir rammir277@gmail.com Zahedan University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: Having at least one year of experience in the production line; giving consent to participate in the study Exclusion criteria: History of chronic diseases of the thyroid, liver, kidney, diabetes, cardiovascular disease, cancer and high blood pressure; use of antioxidant supplements by person; Having Positive test G6PDH no limit no limit Both T52.2 T56.0 T56.3 Homologues of benzene Lead and its compounds Cadmium and its compounds Placebo Placebo The intervention group consists of 20 workers exposed to organic solvents in the printing industry and 20 workers exposed to heavy metals in the tile industry who received capsules 60 mg oral COQ10 twice daily for 60 days. The control group consists of 20 workers exposed to organic solvents in the printing industry and 20 workers exposed to heavy metals in the tile industry who received capsules 60 mg oral placebo twice daily for 60 days. Malondialdehyde. Timepoint: Before the intervention, two months after the intervention. Method of measurement: Measurement of blood plasma levels of malondialdehyde in terms of nmol per ml. Total antioxidant capacity. Timepoint: total antioxidant capacity. Method of measurement: Measurement of antioxidant capacity in blood plasma in terms of micromoles per liter. Superoxide dismutase activity. Timepoint: Before the intervention, two months after the intervention. Method of measurement: Measurment of the level of erythrocyte superoxide dismutase activity in terms of unit per gram of hemoglobin. Glutathione peroxidase activity. Timepoint: Before the intervention, two months after the intervention. Method of measurement: Measurment of the level of erythrocyte glutathione peroxidase activity in terms of unit per gram of hemoglobin. Catalase activity. Timepoint: Before the intervention, two months after the intervention. Method of measurement: Measurment of the level of erythrocyte catalase activity in terms of unit per gram of hemoglobin. Headache. Timepoint: Before the intervention and at the end of intervention. Method of measurement: According to Commenting person. Nausea. Timepoint: Before the intervention and at the end of intervention. Method of measurement: According to Commenting person. Zahedan University of Medical Sciences Approved 2016-06-05 Zahedan University of Medical Sciences Pardis of the University of Medical Sciences, Doctor Hsabi Squre Zahedan Iran (Islamic Republic of)