IRCT201202062560N6 IRCT 2012-02-28 Qom University of Medical Sciences and Health Services Comparison of 3 Protective regimens for preventing contrast-induced nephropathy in high risk patients Comparison of three protective regimens for preventing contrast-induced nephropathy in high risk patients undergoing coronary angiography 2012-02-20 anticipated 147 Complete https://irct.ir/trial/2310 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A Contrast-induced nephropathy. Intervention 1: (1) The sodium bicarbonate solution will be prepared by adding 150 mL of 1000-mEq/L sodium bicarbonate to 850 mL of sodium chloride. Patients will receive the same dose of sodium bicarbonate solution (3mL/ kg/ h) for 1 hour before contrast media, followe by an infusion of 1 mL/kg per hour for 6 hours after the procedure. Intervention 2: (2) All patients will be received the same dose of sodium chloride (1 mL/kg/ h upper limit 100 mL/h) for 12 hours before and 12 hours after the procedure. The study drug (acetylcysteine 600 mg) will be administered orally twice daily for two doses before the procedure and two doses after the procedure. Intervention 3: (3) All patients will be received the same dose of sodium chloride (1 mL/kg/h upper limit 100 mL/h) for 12 hours before and 12 hours after the procedure.