IRCT2016111628756N4 IRCT 2016-12-04 shahid saoughi university of medical science A comparison of Dual triggering by administration of GnRH agonist plus HCG versus HCG in poor responders in ART outcomes A comparison of Dual triggering versus HCG in poor responders in ART outcomes 2016-05-01 anticipated 82 Complete https://irct.ir/trial/23243 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are admitted to two groups of 41 patients on the basis of permutation block method. Therapeutic tasks within the blocks are determined in such a way that they are random, but the desired allocation ratio is achieved in each block. 20 blocks of 4 and a block of 2 are considered. Generate random codes using random block allocation method which will be generated with the help of Random allocation software version 1. The first person eligible to enter the study is given number one and so on until the last person eligible for number 82 is given. Using a table generated by random allocation software by number, people receive intervention A or B. In order to be blind, the random allocation of this list is given to another person outside the study, and by sending a text message before assigning the type of treatment, the eligible person is asked according to the number, and thus the people enter the study. N/A Infertility. Intervention 1: in intervention group co-administration of HCG and agonist used for triggering. Intervention 2: in control group HCG used routinely for triggering. Abstract Background The use of dual triggering in high and normal responders accompanied with better IVF cycle outcomes. Also, it has been suggested that dual triggering in poor responders can be accompanied by better results. Objective The aim of present study was to evaluate whether the Dual trigger, can improve oocyte maturation in poor responder patients based on Bologna criteria and their ART outcomes. Materials and methods All poor ovarian responder's patients underwent GnRH antagonist controlled ovarian hyperstimulation protocols in ART cycles. The participants' randomizations were done and patients divided into two groups. In the first group, final oocyte maturation was done by 6500 I.U.HCG alone. In the second group, triggering was done with coadministration of 6500 I.U.HCG plus 0.2 mg triptorelin simultaneous (dual trigger). Oocyte retrieval was performed 36 h after triggering through transvaginal ultrasound-guided. Routine IVF/ICSI was performed as appropriate. Results The number of retrieved oocytes, number of mature oocytes (MII), number of fertilized oocytes (2PN), number of embryo formation, number of transferred embryos and embryo quality have not significant differences between the two groups (p > 0.05). Also, fertilization and implantation rate, chemical and clinical pregnancy did not differ between groups. Conclusion Dual triggering for final oocyte maturation in poor ovarian responders did not improve the number of mature oocytes (MII) and other ART cycle results. Yes - There is a plan to make this available What will be shared: All participant data sets are to be shared When: 2 months after the result publication To whom: A journal in which the results are published Conditions: Submission of an official application via the agent that is legally in charge Where to obtain: Yazd Reproductive Sciences Institute How to obtain: Submission of an official application Comments: