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IRCT138902232576N2 IRCT 2010-09-09 Tehran university of medical sciences Effects of stimulation of endometrium before embryo transfer on pregnancy rates in patients undergoing assisted reproduction Effects of stimulation of endometrium before embryo transfer on pregnancy rates in patients undergoing assisted reproduction 2009-09-01 anticipated 90 Complete https://irct.ir/trial/2328 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 Infertility. Intervention 1: Intervention: Media that blastocyst has developed on it inserted via transcervical in 17th day and then blastocyst transfer is in 20th day. Intervention 2: Control: blastocyst transfer is done at 20th day of cycle without media transfer on 17th day. Arch Gynecol Obstet. 2012 Apr;285(4):1167-71. doi: 10.1007/s00404-011-2143-z. Epub 2011 Nov 20.<br /> Stimulation of the endometrium with high-grade blastocyst culture supernatant (SEHB) can improve pregnancy outcome for couples undergoing intracytoplasmic sperm injection (ICSI): a randomized clinical trial.<br /> Tehraninejad ES1, Tanha FD, Ghajarzadeh M, Zandieh Z, Aziminekoo E, Zanjani HR.<br /> Author information<br /> Abstract<br /> PURPOSE:<br /> To evaluate the impact of stimulating the endometrium with high-grade blastocyst culture supernatant (SEHB) perfusion before blastocyst transfer (BT) on implantation rate, pregnancy rate, and pregnancy outcome in ICSI cycles.<br /> MATERIALS AND METHODS:<br /> Ninety-four infertile couples who were referred to the Valiasr department of Imam Hospital complex between January 2010 and March 2011 enrolled in this randomized clinical trial. They were randomly divided into only BT or SEHB groups. Implantation rates, pregnancy rates, abortion, preterm and term delivery rates were compared between the two groups.<br /> RESULTS:<br /> Implantation rates and pregnancy rates did not differ significantly between the two groups. The abortion rate was significantly higher in the BT only group while term delivery was significantly higher in SEHB group. Odds ratios of term delivery and abortion were 4.5 (p = 0.001) and 0.3 (p = 0.04), respectively.<br /> CONCLUSION:<br /> The SEHB application may improve pregnancy outcome in infertile couples who are candidates for the ICSI reproductive method.<br /> PMID:<br /> <br /> 22101499<br /> <br />
public Fatemeh Davari Tanha
Women's hospital, Ostad Nejatollahi Shomally Avenue, Karim khan Zand bridge
Tehran Iran (Islamic Republic of) 15978 +98 982188313955 fdavaritanha@sina.tums.ac.ir Tehran university of medical sciences scientific Fatemeh Davari Tanha
Women's hospital, Ostad Nejatollahi Shomally Avenue, Karim khan Zand bridge
Tehran Iran (Islamic Republic of) 15978 +98 21 8831 3955 fdavaritanha@sina.tums.ac.ir Tehran university of medical sciences Iran (Islamic Republic of) Inclusion criteria: All women with infertility who refer to infertility clinic of Valiasr reproductive health research center, age 20-38, infertility<10y Exclusion criteria: Age>38, Hydrosalpinx, FSH>10, History of IVF failure 20 years 39 years Female N97 Female infertility Treatment - Other N/A Intervention: Media that blastocyst has developed on it inserted via transcervical in 17th day and then blastocyst transfer is in 20th day Control: blastocyst transfer is done at 20th day of cycle without media transfer on 17th day Chemical pregnancy. Timepoint: After14 days of embryo transfer. Method of measurement: B-hcG. Clinical pregnancy. Timepoint: 13 weeks. Method of measurement: Trans vaginal sonography. Tehran university of medical sciences Approved 2009-11-12 Ethics committee of Tehran university of medical sciences Tehran university medical sciences, 6th floor, Central Building of Tehran University of Medical Sciences, Keshavarz Boulevard, Ghods Avenue TEHRAN Iran (Islamic Republic of)