IRCT2016090728950N3 IRCT 2016-11-26 Shahid Sadoughi University of Medical Sciences, Vice chancellor for research Intrauterine infusion of autologous platelet rich plasma (PRP) on women with repeated frozen thawed cycles failure Clinical trail of comparison of pregnancy outcome in women with history of repeated implantation failure after intrauterine infusion of autologous platelet rich plasma (PRP) and women without intervention undergoing frozen thawed cycles 2016-09-22 anticipated 66 Complete https://irct.ir/trial/23378 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomized allocation with computerized program we divide the patients randomly in intervention and control groups with table of random numbers. 3 female infertility. Intervention 1: Intervention group:In 2nd day of cycle the patients undergo a basic trans vaginal sonography. For all the women who enter in frozen thawed cycles, estradiol tablet 2mg three times daily is initiated. In 13th day of cycle trans vaginal sonograghy is done for the patients again. Those who have endometrial thickness above 8mm enter in the study .They are divided in 2 groups randomly. In interventional group PRP (plasma riches platelet) is infused intrauterine with IUI catheter. Then Progesterone vaginal suppository 400 mg twice daily is prescribed for 3 days and embryos in cleavage state are transferred. . Intervention 2: Control group: In 2nd day of cycle the patients undergo a basic trans vaginal sonography. For all the women who enter in frozen thawed cycles, estradiol tablet 2mg three times daily is initiated. In 13th day of cycle trans vaginal sonograghy is done for the patients again. Those who have endometrial thickness above 8mm enter in the study .They are divided in 2 groups randomly. In control group, they continue routine protocol and Progesterone vaginal suppository 400 mg twice daily is prescribed for 3 days then embryos in cleavage state are transferred.