IRCT20160827029535N3 IRCT 2018-01-30 Investigator The comparison of the efficacy of two combined therapeutic regimens in the treatment of gastroesophageal reflux disease in term neonates The comparison of the efficacy of ranitidine plus metoclopramide with lansoprazole plus metoclopramide in the recovery rate of signs and symptoms of neonatal gastro esophageal reflux disease unresponsive to conservative and monotherapy. 2018-03-21 anticipated 60 Complete https://irct.ir/trial/23714 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization at the individual level and using random number table with allocation concealment by sequentially numbered sealed opaque envelop, Blinding description: The participants; the physicians who care the participants; the researcher who collects the data and the person who analyses the data are blind to the study. N/A Gastroesophageal reflux in mature neonate. Intervention 1: In group 1 intervention: Ranitidine 2 mg/kg TDS plus metoclopramide 0/15 mg/kg TDS for one month. Intervention 2: In group 2 intervention: lansoprazole 0/7 mg/kg/BID plus metoclopramide 0/15 mg/kg TDS for one month. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more available data